Leucomycin A5
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Category | Antibiotics |
Catalog number | BBF-02649 |
CAS | 18361-45-0 |
Molecular Weight | 771.94 |
Molecular Formula | C39H65NO14 |
Purity | >98% by HPLC |
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Description
It is produced by the strain of Str. kitasatoensis. It's a macrolide antibiotic. It has strong anti-gram-positive bacterial effect, and also has an effect on spirochetes, rickettsium and Chlamydia. After the C3 position on the lactone ring in the structure is acetylated, the activity in vitro is reduced, but the activity in vivo is enhanced, and the toxicity is also reduced. The antibacterial activity of Leucomycin group A is stronger than group B. It has been used in clinical and the indications are the same as erythromycin.
Specification
Synonyms | Kitasamycin A5; Turimycin H4; Leukomycin A5; Leucomycin V 4''-butanoate |
Storage | Store at -20°C |
IUPAC Name | [(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-4,10-dihydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] butanoate |
Canonical SMILES | CCCC(=O)OC1C(OC(CC1(C)O)OC2C(OC(C(C2N(C)C)O)OC3C(CC(C(C=CC=CCC(OC(=O)CC(C3OC)O)C)O)C)CC=O)C)C |
InChI | InChI=1S/C39H65NO14/c1-10-14-29(44)52-37-25(5)50-31(21-39(37,6)47)53-34-24(4)51-38(33(46)32(34)40(7)8)54-35-26(17-18-41)19-22(2)27(42)16-13-11-12-15-23(3)49-30(45)20-28(43)36(35)48-9/h11-13,16,18,22-28,31-38,42-43,46-47H,10,14-15,17,19-21H2,1-9H3/b12-11+,16-13+/t22-,23-,24-,25+,26+,27+,28-,31+,32-,33-,34-,35+,36+,37+,38+,39-/m1/s1 |
InChI Key | JZVYPSLDMXOITF-MJRCUCNNSA-N |
Source | Streptomyces kisatoensis |
Properties
Appearance | White Columnar Crystal |
Antibiotic Activity Spectrum | Gram-positive bacteria; Mycoplasma |
Boiling Point | 871.4°C at 760 mmHg |
Melting Point | 120-123°C |
Density | 1.22 g/cm3 |
Solubility | Soluble in Methanol, Chloroform, Ethanol, DMF, DMSO; Poorly soluble in Water |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2