M-230B
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| Category | Antibiotics |
| Catalog number | BBF-03632 |
| CAS | |
| Molecular Weight | 621.84 |
| Molecular Formula | C35H59NO8 |
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Description
M-230B is originally isolated from Myxococcus xanthus M516E. It has anti-gram-negative and weak anti-gram-positive activity.
Specification
| IUPAC Name | (12Z,14E,26E)-16-ethyl-6,8,9-trihydroxy-12-(methoxymethyl)-25,27-dimethyl-2-propyl-1-oxa-4-azacyclooctacosa-12,14,26-triene-3,20,28-trione |
| Canonical SMILES | CCCC1C(=O)NCC(CC(C(CCC(=CC=CC(CCCC(=O)CCCCC(C=C(C(=O)O1)C)C)CC)COC)O)O)O |
| InChI | InChI=1S/C35H59NO8/c1-6-12-33-34(41)36-23-30(38)22-32(40)31(39)20-19-28(24-43-5)16-10-14-27(7-2)15-11-18-29(37)17-9-8-13-25(3)21-26(4)35(42)44-33/h10,14,16,21,25,27,30-33,38-40H,6-9,11-13,15,17-20,22-24H2,1-5H3,(H,36,41)/b14-10+,26-21+,28-16- |
| InChI Key | CANOHYLGAOUVMU-JCRVAUONSA-N |
Properties
| Appearance | Colorless Acicular Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
| Boiling Point | 802.5±65.0°C at 760 mmHg |
| Melting Point | 113°C |
| Density | 1.0±0.1 g/cm3 |
Reference Reading
1. A macrocyclic antibiotic M-230B produced by Myxococcus xanthus. Isolation and characterization
N Onishi, K Izaki, H Takahashi J Antibiot (Tokyo). 1984 Jan;37(1):13-9. doi: 10.7164/antibiotics.37.13.
Myxococcus xanthus strain M516E produced at least three related antibiotics against Gram-positive and Gram-negative bacteria. From physico-chemical properties, a main component was identical to myxovirescin A and a second component, designated M-230B was found to be an antibiotic which is closely related to myxovirescin A. The structure of M-230B was determined from its physico-chemical properties, especially from 13C NMR spectrum as compared with that of myxovirescin A. The addition of alcohol, such as isobutyl alcohol, to the culture medium markedly stimulated production of the antibiotics.
2. Novel macrocyclic antibiotics: megovalicins A, B, C, D, G and H. II. Isolation and chemical structures of megovalicins
S Takayama, S Yamanaka, S Miyashiro, Y Yokokawa, H Shibai J Antibiot (Tokyo). 1988 Apr;41(4):439-45. doi: 10.7164/antibiotics.41.439.
Myxococcus flavescens AJ12298 was found to produce the complex of macrocyclic antibiotics named megovalicins. The physico-chemical studies revealed that megovalicins C and B were identical to myxovirescin A1 and antibiotic M-230B, respectively, and that megovalicins A, D, G and H were closely related new antibiotics.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
