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m-Scrobiculin

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m-Scrobiculin
Category Others
Catalog number BBF-04963
CAS 15081-04-6
Molecular Weight 418.44
Molecular Formula C22H26O8

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

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Synonyms Scrobiculin
IUPAC Name methyl 2,4-dihydroxy-3-(2-hydroxy-4-methoxy-6-propylbenzoyl)oxy-6-propylbenzoate
Canonical SMILES CCCC1=CC(=C(C(=C1C(=O)OC)O)OC(=O)C2=C(C=C(C=C2O)OC)CCC)O
InChI InChI=1S/C22H26O8/c1-5-7-12-9-14(28-3)11-15(23)17(12)22(27)30-20-16(24)10-13(8-6-2)18(19(20)25)21(26)29-4/h9-11,23-25H,5-8H2,1-4H3
InChI Key CFXORXZRGPTGFD-UHFFFAOYSA-N
1. Cytotoxic constituents from Lobaria scrobiculata and a comparison of two bioassays for their evaluation
Andreas Schinkovitz, Aman Kaur, Ernst Urban, Martin Zehl, Gabriela Páchniková, Yuehong Wang, Nadine Kretschmer, Iva Slaninová, Guido F Pauli, Scott G Franzblau, Georg Krupitza, Rudolf Bauer, Brigitte Kopp J Nat Prod. 2014 Apr 25;77(4):1069-73. doi: 10.1021/np4008574. Epub 2014 Apr 11.
Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, with two of these compounds, 2 and 3, exhibiting cytotoxicity against HL-60 cells. In order to verify the potential impact of degradation on observed bioactivity, a purity and stability evaluation was conducted. The consistency of results obtained by the water-soluble tetrazolium salt-1 assay and trypan blue cytotoxicity assay was evaluated for selected compounds.

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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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