Madindoline B
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Category | Enzyme inhibitors |
Catalog number | BBF-02290 |
CAS | 184877-65-4 |
Molecular Weight | 369.45 |
Molecular Formula | C22H27NO4 |
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Description
It is produced by the strain of Str. sp. K93-0711. It is an interleukin-6 inhibitor. It inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with IC50 of 30 μmol/L. It has no antimicrobial effect.
Specification
Synonyms | Antibiotic K93-0711 I2; (S)-4-butyl-2-(((3aR,8aS)-3a-hydroxy-2,3,3a,8a-tetrahydro-8H-furo[2,3-b]indol-8-yl)methyl)-2,5-dimethylcyclopent-4-ene-1,3-dione; (+)-Madindoline B |
IUPAC Name | (2S)-2-[[(3aS,8bR)-8b-hydroxy-2,3a-dihydro-1H-furo[2,3-b]indol-4-yl]methyl]-4-butyl-2,5-dimethylcyclopent-4-ene-1,3-dione |
Canonical SMILES | CCCCC1=C(C(=O)C(C1=O)(C)CN2C3C(CCO3)(C4=CC=CC=C42)O)C |
InChI | InChI=1S/C22H27NO4/c1-4-5-8-15-14(2)18(24)21(3,19(15)25)13-23-17-10-7-6-9-16(17)22(26)11-12-27-20(22)23/h6-7,9-10,20,26H,4-5,8,11-13H2,1-3H3/t20-,21-,22+/m0/s1 |
InChI Key | XPVQXXLKOCZMGG-FDFHNCONSA-N |
Properties
Appearance | Pale Yellow Crystal |
Antibiotic Activity Spectrum | Neoplastics (Tumor) |
Melting Point | 105-107°C |
Solubility | Soluble in Methanol, Ethanol, Chloroform, Ethyl Acetate, Acetone, Water |
Reference Reading
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2