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Maniwamycin A

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Maniwamycin A
Category Antibiotics
Catalog number BBF-02292
CAS 122566-70-5
Molecular Weight 198.26
Molecular Formula C10H18N2O2

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Str. prasinopilosus KC-7367. It has anti-fungal effect. Maniwamycin A has stronger anti-fungal effect than Maniwamycin B, but it has no anti-bacterial effect.

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Synonyms Antibiotic KA 7367A; KA 7367A; (S-(Z,E))-3-(1-Hexenyl-ONN-azoxy)-2-butanone
IUPAC Name [(E)-hex-1-enyl]-oxido-[(2S)-3-oxobutan-2-yl]iminoazanium
Canonical SMILES CCCCC=C[N+](=NC(C)C(=O)C)[O-]
InChI InChI=1S/C10H18N2O2/c1-4-5-6-7-8-12(14)11-9(2)10(3)13/h7-9H,4-6H2,1-3H3/b8-7+,12-11?/t9-/m0/s1
InChI Key WFHYSKXBQMLHKH-JFLSSZQFSA-N
Appearance Colorless Oily Matter
Antibiotic Activity Spectrum Fungi
Boiling Point 279.3°C at 760 mmHg
Density 0.98 g/cm3
Solubility Soluble in Chloroform, Ethanol
1. Novel antifungal antibiotics maniwamycins A and B. II. Structure determination
Y Takahashi, M Nakayama, I Watanabe, T Deushi, H Ishiwata, M Shiratsuchi, G Otani J Antibiot (Tokyo). 1989 Nov;42(11):1541-6. doi: 10.7164/antibiotics.42.1541.
The structures of the new azoxy antibiotics maniwamycins A and B have been determined by means of spectral analyses and chemical studies.
2. Novel antifungal antibiotics maniwamycins A and B. I. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological properties
M Nakayama, Y Takahashi, H Itoh, K Kamiya, M Shiratsuchi, G Otani J Antibiot (Tokyo). 1989 Nov;42(11):1535-40. doi: 10.7164/antibiotics.42.1535.
Two antifungal antibiotics maniwamycins A and B were isolated from the culture broth of a strain of actinomycetes, which were classified as Streptomyces prasinopilosus. These antibiotics were isolated by resin absorption and extraction with EtOAc and purified by column chromatography. Both antibiotics were found to be new azoxy substances from their physico-chemical properties. They showed broad antifungal spectra.

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