Melanoxazal
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| Category | Enzyme inhibitors |
| Catalog number | BBF-02322 |
| CAS | |
| Molecular Weight | 167.16 |
| Molecular Formula | C8H9NO3 |
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Description
It is produced by the strain of Trichoderma sp. ATF-451. It is a Melanin biosynthesis inhibitor. It can inhibit melanin formation in the silkworm larva hemolymph (IC50 is 30.1 μg/mL), and also has stronger inhibitory effect against mushroom tyrosinase (IC50 is 4.2 μg/mL), but it has no antimicrobial effect.
Specification
| IUPAC Name | (2E)-3-hydroxy-2-(1,3-oxazol-4-ylmethylidene)butanal |
| Canonical SMILES | CC(C(=CC1=COC=N1)C=O)O |
| InChI | InChI=1S/C8H9NO3/c1-6(11)7(3-10)2-8-4-12-5-9-8/h2-6,11H,1H3/b7-2- |
| InChI Key | BZXLEEHULFONSG-UQCOIBPSSA-N |
Properties
| Appearance | White Powder |
| Melting Point | 70-73°C |
| Solubility | Soluble in Methanol |
Reference Reading
1. Melanoxazal, new melanin biosynthesis inhibitor discovered by using the larval haemolymph of the silkworm, Bombyx mori. Production, isolation, structural elucidation, and biological properties
S Takahashi, R Hashimoto, K Hamano, T Suzuki, A Nakagawa J Antibiot (Tokyo). 1996 Jun;49(6):513-8. doi: 10.7164/antibiotics.49.513.
A new melanin biosynthesis inhibitor, melanoxazal, was isolated from the fermentation broth of Trichoderma sp. ATF-451 by successive purification procedures of carbon adsorption, ethyl acetate extraction and silica gel column chromatography. The inhibitor possesses a novel oxazole-containing structure with molecular formula, C8H9NO3. The structure was determined by means of NMR analyses to be (E)-4-(2'-formyl-3'-hydroxybuten-1'-yl) oxazole, which is related to melanoxadin. Melanoxazal inhibited melanin formation in the larval haemolymph of the silkworm, Bombyx mori; IC50 value = 30.1 micrograms/ml. Melanoxazal also showed a strong inhibitory activity against mushroom tyrosinase with IC50 value = 4.2 micrograms/ml.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
