August 17–21, 2025, Washington, DC, USA - Visit us at Booth 2230.

Email:
Phone:

Get A Quote

Melithiazol C

Name: Melithiazol C
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Antibiotics
Catalog number	BBF-01908
CAS	214420-47-0
Molecular Weight	339.41
Molecular Formula	C16H21NO5S

Online Inquiry

Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Melithiazol C is an antibiotic produced by Melittangium lichenicila Mel26, Archangium gephyra Ar 7747 and Myxococcus stipitatus Mx s 64. It is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal agent.

Specification
Properties
Reference Reading
Price Product List

Synonyms	Melithiazole C; Melithiazol-C
IUPAC Name	methyl (2E,4R,5S,6E)-7-(2-acetyl-1,3-thiazol-4-yl)-3,5-dimethoxy-4-methylhepta-2,6-dienoate
Canonical SMILES	CC(C(C=CC1=CSC(=N1)C(=O)C)OC)C(=CC(=O)OC)OC
InChI	InChI=1S/C16H21NO5S/c1-10(14(21-4)8-15(19)22-5)13(20-3)7-6-12-9-23-16(17-12)11(2)18/h6-10,13H,1-5H3/b7-6+,14-8+/t10-,13+/m1/s1
InChI Key	LTTPICLGJAXUOJ-NSTYSWHMSA-N

Appearance	Oil
Antibiotic Activity Spectrum	fungi
Boiling Point	485.7±55.0°C at 760 mmHg
Density	1.2±0.1 g/cm3

1. Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria. Production, isolation, physico-chemical and biological properties

F Sasse, B Böhlendorf, M Herrmann, B Kunze, E Forche, H Steinmetz, G Höfle, H Reichenbach J Antibiot (Tokyo). 1999 Aug;52(8):721-9. doi: 10.7164/antibiotics.52.721.

New antibiotic compounds, melithiazols, were isolated from the culture broth of strains of the myxobacteria Melittangium lichenicola, Archangium gephyra, and Myxococcus stipitatus. The compounds belong to the group of beta-methoxyacrylate (MOA) inhibitors and are related to the myxothiazols. The melithiazols show high antifungal activity, but are less toxic than myxothiazol A and its methyl ester in a growth inhibition assay with mouse cell cultures. The melithiazols inhibit NADH oxidation by submitochondrial particles from beef heart. Melithiazol A blocks the electron transport within the bc1-segment (complex III) and causes a red shift in the reduced spectrum of cytochrome b.

2. A concise total synthesis of melithiazole C

Julian Gebauer, Stellios Arseniyadis, Janine Cossy Org Lett. 2007 Aug 16;9(17):3425-7. doi: 10.1021/ol701459j. Epub 2007 Jul 18.

A short and convergent synthesis of the myxobacterial antibiotic melithiazole C is described featuring a highly E-selective cross-metathesis as the key step.

BBF-05886	Notoginsenoside R1	Inquiry
BBF-01825	Loganin	Inquiry
BBF-03781	Resveratrol	Inquiry
BBF-03794	Geneticin sulfate	Inquiry
BBF-02576	Pneumocandin B0	Inquiry
BBF-00968	Homoalanosine	Inquiry

Bio Calculators

Solution Dilution Calculator
Molecular Weight Calculator
Molarity Calculator

Stock concentration: *

Desired final volume: *

Desired concentration: *

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂

Calculate

* Total Molecular Weight:

g/mol

Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳

Formula weight: *

g/mol

Desired final volume: *

Desired concentration: *

Online Inquiry

*Name:

*Phone:

*Email:

*Quantity:

*Service & Products Interested:

Project Description:

Melithiazol C

Capabilities & Facilities

Product Description

Bio Calculators

Recently viewed products

Online Inquiry