Melrosporus
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| Category | Antibiotics |
| Catalog number | BBF-01916 |
| CAS | 102367-17-9 |
| Molecular Weight | 147.13 |
| Molecular Formula | C5H9NO4 |
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Description
Melrosporus is an antibiotic produced by Streptovertieillium fervens var. melrosporus NRRL 3117. It has an anti-bacterial effect.
Specification
| IUPAC Name | N-hydroxy-N-methoxy-4-oxobutanamide |
| Canonical SMILES | CON(C(=O)CCC=O)O |
| InChI | InChI=1S/C5H9NO4/c1-10-6(9)5(8)3-2-4-7/h4,9H,2-3H2,1H3 |
| InChI Key | FWGWGVQEZXKOOR-UHFFFAOYSA-N |
Properties
| Appearance | White Crystals |
| Antibiotic Activity Spectrum | bacteria |
| Boiling Point | 300.6±44.0°C at 760 mmHg |
| Melting Point | 130-132°C |
| Density | 1.2±0.1 g/cm3 |
Reference Reading
1. Rhizopus microsporus as Causative Agent of Mucormycosis in COVID-19 Patient
Moslem Sedaghatalab, Sadegh Nouripour-Sisakht, Seyed R Cheraghzadeh, Gholamabas Sabz, Maral Gharaghani Clin Lab. 2022 Dec 1;68(12). doi: 10.7754/Clin.Lab.2022.220232.
Background: The pandemic of coronavirus disease (COVID-19) emerged as a fatal infection, especially in immunocompromised patients. Currently, this infection is managed with systemic corticosteroids. Co-infection of CO-VID-19 with opportunistic fungi is increasingly recognized. Methods: We describe a case of rhino-cerebral mucormycosis 12 days following severe COVID-19 in a diabetic patient. Results: He received 50 mg amphotericin B and surgical debridement. The patient's symptoms improved following medical and surgical intervention. Conclusions: Mucormycosis is an uncommon but serious infection that complicates the course of severe COVID-19. Subjects with diabetes mellitus and multiple risk factors may be at a higher risk for developing mucormycosis.
2. Transformation and CRISPR-Cas9-mediated homologous recombination in the fungus Rhizopus microsporus
Carlos Lax, María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Eusebio Navarro, Francisco Esteban Nicolás, Victoriano Garre STAR Protoc. 2022 Mar 14;3(1):101237. doi: 10.1016/j.xpro.2022.101237. eCollection 2022 Mar 18.
Here, we describe a reliable approach for targeted DNA integrations in the genome of R. microsporus, one of the main causal agents of mucormycosis. We provide a strategy for stable, targeted integration of DNA templates by homologous recombination (HR) based on the CRISPR-Cas9 technology. This strategy opens a wide range of possibilities for the genetic modification of R. microsporus and will be useful for the study of mucormycosis. For complete details on the use and execution of this protocol, please refer to Lax et al. (2021).
3. Endofungal Mycetohabitans rhizoxinica Bacteremia Associated with Rhizopus microsporus Respiratory Tract Infection
Shangxin Yang, Victoria Anikst, Paul C Adamson Emerg Infect Dis. 2022 Oct;28(10):2091-2095. doi: 10.3201/eid2810.220507.
We report Mycetohabitans rhizoxinica bacteremia in a 65-year-old woman in California, USA, who was undergoing chimeric antigen receptor T-cell therapy for multiple myeloma. Acute brain infarction and pneumonia developed; Rhizopus microsporus mold was isolated from tracheal suction. Whole-genome sequencing confirmed bacteria in blood as genetically identical to endofungal bacteria inside the mold.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
