Mer-A2026A
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03646 |
| CAS | |
| Molecular Weight | 413.59 |
| Molecular Formula | C26H39NO3 |
Online Inquiry
Description
It is originally isolated from Streptomyces pactum. Mer-A2026A has the function of vasodilator and hypotension.
Specification
| Synonyms | Mer-A-2026A |
| IUPAC Name | 2-[(2E,5E,7E,11E)-10-hydroxy-3,7,9,11,13-pentamethyltetradeca-2,5,7,11-tetraenyl]-6-methoxy-3-methyl-1H-pyridin-4-one |
| Canonical SMILES | CC1=C(NC(=CC1=O)OC)CC=C(C)CC=CC(=CC(C)C(C(=CC(C)C)C)O)C |
| InChI | InChI=1S/C26H39NO3/c1-17(2)14-20(5)26(29)21(6)15-19(4)11-9-10-18(3)12-13-23-22(7)24(28)16-25(27-23)30-8/h9,11-12,14-17,21,26,29H,10,13H2,1-8H3,(H,27,28)/b11-9+,18-12+,19-15+,20-14+ |
| InChI Key | CHFFBNSQZJTFMA-HPVRZXAJSA-N |
Properties
| Appearance | Yellow Oily Matter |
| Boiling Point | 568.3±50.0°C at 760 mmHg |
| Density | 1.0±0.1 g/cm3 |
Reference Reading
1. Mer-A2026A and B, novel piericidins with vasodilating effect. I. Producing organism, fermentation, isolation and biological properties
K Kominato, Y Watanabe, S Hirano, T Kioka, T Terasawa, T Yoshioka, K Okamura, H Tone J Antibiot (Tokyo). 1995 Feb;48(2):99-102. doi: 10.7164/antibiotics.48.99.
A strain of Streptomyces was found to produce new piericidins. The compounds were purified and separated into two substances named Mer-A2026A and B. These new piericidins exhibited vasodilating and depressor activities.
2. Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons
Takayuki Kondo, Tsuyoshi Yamamoto, Kaoru Okayama, Hideki Narumi, Haruhisa Inoue Sci Rep. 2022 Mar 2;12(1):2690. doi: 10.1038/s41598-022-06513-z.
Microbial flora is investigated to be related with neuropathological conditions in Alzheimer's disease (AD), and is attracting attention as a drug discovery resource. However, the relevance between the soil microbiota and the pathological condition has not been fully clarified due to the difficulty in isolation culture and the component complexity. In this study, we established a library of secondly metabolites produced in microorganism to investigate the potential effect of microorganisms on the production of amyloid β (Aβ), one of the most representative pathogens of AD. We conducted a library screening to quantify Aβ and neuronal toxicity by using cortical neurons from human induced pluripotent stem cells (iPSCs) of AD patients after adding secondary metabolites. Screening results and following assessment of dose-dependency identified Verrucarin A, produced in Myrothecium spp., showed 80% decrease in Aβ production. Furthermore, addition of Mer-A2026A, produced in Streptomyces pactum, showed increase in Aβ42/40 ratio at the low concentration, and decrease in Aβ production at the higher concentration. As a result, established library and iPSC-based phenotyping assay clarified a direct link between Aβ production and soil microorganisms. These results suggest that Aβ-microorganism interaction may provide insight into the AD pathophysiology with potential therapeutics.
3. Mer-A2026A and B, novel piericidins with vasodilating effect. II. Physico-chemical properties and chemical structures
K Kominato, Y Watanabe, S Hirano, T Kioka, T Terasawa, T Yoshioka, K Okamura, H Tone J Antibiot (Tokyo). 1995 Feb;48(2):103-5. doi: 10.7164/antibiotics.48.103.
The structure of vasodilating active substances, Mer-A2026A and B, produced by Streptomyces pactum Me2108 were determined on the basis of their spectral and chemical properties.
Recommended Products
| BBF-01829 | Deoxynojirimycin | Inquiry |
| BBF-03755 | Actinomycin D | Inquiry |
| BBF-01693 | Doxorubicin EP Impurity A (Daunorubicin) | Inquiry |
| BBF-00677 | 3-Amino-3-deoxy-D-glucose | Inquiry |
| BBF-01825 | Loganin | Inquiry |
| BBF-03754 | CASTANOSPERMINE | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
