Mer-NF5003E
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| Category | Enzyme inhibitors |
| Catalog number | BBF-03218 |
| CAS | 159121-98-9 |
| Molecular Weight | 388.50 |
| Molecular Formula | C23H32O5 |
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Description
Mer-NF5003E is a myo-inositol monophosphatase (IMPase) inhibitor produced by Memnoniella echinata.
Specification
| Synonyms | Mer NF5003E; (2R,2'R,4'aS,6'R,8'aS)-2',4-dihydroxy-6-(hydroxymethyl)-1',1',4'a,6'-tetramethyl-spiro[3H-benzofuran-2,5'-decalin]-7-carbaldehyde; (2R,2'R,4a'S,6'R,8a'S)-4,6'-Dihydroxy-6-(hydroxymethyl)-2',5',5',8a'-tetramethyl-3',4',4a',5',6',7',8',8a'-octahydro-2'H,3H-spiro[1-benzofuran-2,1'-naphthalene]-7-carbaldehyde |
| IUPAC Name | (3R,4aS,7R,8R,8aS)-3,4'-dihydroxy-6'-(hydroxymethyl)-4,4,7,8a-tetramethylspiro[2,3,4a,5,6,7-hexahydro-1H-naphthalene-8,2'-3H-1-benzofuran]-7'-carbaldehyde |
| Canonical SMILES | CC1CCC2C(C(CCC2(C13CC4=C(C=C(C(=C4O3)C=O)CO)O)C)O)(C)C |
| InChI | InChI=1S/C23H32O5/c1-13-5-6-18-21(2,3)19(27)7-8-22(18,4)23(13)10-15-17(26)9-14(11-24)16(12-25)20(15)28-23/h9,12-13,18-19,24,26-27H,5-8,10-11H2,1-4H3/t13-,18+,19-,22+,23-/m1/s1 |
| InChI Key | QKXGRPHIBLICSC-QJAXDWLUSA-N |
Properties
| Appearance | White Powder |
| Boiling Point | 570.1±50.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C. Isolation, physico-chemical characterization and biological properties
S Stefanelli, C Sottani, C Brunati, K Islam, P Ferrari, E Corti, F Sponga J Antibiot (Tokyo) . 1996 Jul;49(7):611-6. doi: 10.7164/antibiotics.49.611.
During the course of a screening program for inhibitors of myo-inositol monophosphatase we fermented the strain ATCC 20928, a known producer of L-671,776. We now show that this strain produces a complex of at least three sesquiterpenic compounds, L-671,776 (termed factor B) and two structurally related substances, termed factors A and C. Both factors A and C, like L-671,776, exhibited inhibitory activity against myo-inositol monophosphatase. Six other fungi producing the above mentioned compounds were also isolated and taxonomically characterized.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
