Meropenem Trihydrate
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| Category | Antibiotics |
| Catalog number | BBF-04632 |
| CAS | 119478-56-7 |
| Molecular Weight | 437.51 |
| Molecular Formula | C17H25N3O5S.3H2O |
| Purity | 98% |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-04632 | 100 mg | $199 | In stock |
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Add to cartDescription
Meropenem Trihydrate is a carbapenem antibiotic, which has broad spectrum antibacterial activity.
Specification
| Related CAS | 96036-03-2 (free base) |
| Synonyms | [4R-[3(3S*,5S*),4α,5β,6β(R*)]]-3-[[5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate; (4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate; SM-7338 |
| Storage | Store at 2-8°C |
| IUPAC Name | (4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate |
| Canonical SMILES | CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O |
| InChI | InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1../s1 |
| InChI Key | CTUAQTBUVLKNDJ-OBZXMJSBSA-N |
| Source | Synthetic |
Properties
| Appearance | White to Pale Yellow Solid |
| Antibiotic Activity Spectrum | Bacteria |
| Boiling Point | 627.4°C at 760 mmHg |
| Melting Point | >192°C (dec.) |
| Density | 1.42 g/cm3 |
| Solubility | Slightly soluble in DMSO, Methanol, Water |
Reference Reading
1.A validated reverse phase HPLC method for the determination of disodium EDTA in meropenem drug substance with UV-detection using precolumn derivatization technique.
Narola B1, Singh AS, Mitra M, Santhakumar PR, Chandrashekhar TG. Anal Chem Insights. 2011;6:7-14. doi: 10.4137/ACI.S5953. Epub 2011 Feb 23.
This paper deals with development and validation of a high performance liquid chromatographic method for the quantitative determination of disodium EDTA (Ethylenediaminetetraacetic acid) in Meropenem active pharmaceutical ingredient (API). EDTA was derivatized with Ferric chloride solution by heating at 70 °C in water bath for about 20 minutes and the chromatographic separation achieved by injecting 100 μL of the derivatized mixture into a Waters HPLC system with photodiode array detector using a Phenomenex Luna C18(2) column (250 × 4.6 mm), 5 μ. The mobile phase consisting of 5% methanol and 95% of 0.7 g/L solution of Tetra butyl ammonium bromide and 4.6 g/L solution of sodium acetate trihydrate in water (pH adjusted to 4.0 with the help of acetic acid glacial) and a flow rate of 1 milliliter/minute. EDTA eluted at approximately 6 minutes. The method was suitably validated with respect to specificity, linearity of response, precision, accuracy, ruggedness, stability in analytical solution, limit of quantitation and detection and robustness for its intended use.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
