Methyl 2,7-dichloropsoromate
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| Category | Others |
| Catalog number | BBF-05265 |
| CAS | 131840-47-6 |
| Molecular Weight | 441.22 |
| Molecular Formula | C19H14Cl2O8 |
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Description
Methyl 2,7-dichloropsoromate, the depsidone, has been isolated from the lichen Phyllopsora corallina var. ochroxantha.
Specification
| Synonyms | 2,7-Dichloro-4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid methyl ester |
| IUPAC Name | methyl 2,7-dichloro-4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylate |
Properties
| Appearance | Crystal |
| Melting Point | 204.5-207°C (water) |
| Solubility | Soluble in Ethanol |
Reference Reading
1. Nanoscale Force-Mapping-Based Quantification of Low-Abundance Methylated DNA
Woo Cheol Shim, Sungwook Woo, Joon Won Park Nano Lett. 2022 Feb 9;22(3):1324-1330. doi: 10.1021/acs.nanolett.1c04637. Epub 2022 Jan 26.
Methylation changes at cytosine-guanine dinucleotide (CpG) sites in genes are closely related to cancer development. Thus, detection and quantification of low-abundance methylated DNA is critical for early diagnosis. Here, we report an atomic force microscopy (AFM)-based quantification method for DNA that contains methyl-CpG at a specific site, without any treatment to the target DNA such as chemical labeling, fluorescence tagging, or amplification. We employed AFM-tip-tethered methyl-CpG-binding proteins to probe surface-captured methylated DNA. We observed a linear correlation (R2 = 0.982) between the input copy number and detected copy number, in the low copy number regime (10 or fewer; subattomolar concentrations). For a mixture of methylated and nonmethylated DNA that resembles clinical samples, we were still able to quantify the methylated DNA. These results highlight the potential of our force-mapping-based quantification method for wide applications in early detection of diseases associated with methylated DNA.
2. The molecular structure and biological functions of RNA methylation, with special emphasis on the roles of RNA methylation in autoimmune diseases
Wanwan Zhou, Xiao Wang, Jun Chang, Chenglong Cheng, Chenggui Miao Crit Rev Clin Lab Sci. 2022 May;59(3):203-218. doi: 10.1080/10408363.2021.2002256. Epub 2021 Nov 13.
Autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic vasculitis are caused by the body's immune response to autoantigens. The pathogenesis of autoimmune diseases is complex. RNA methylation is known to play a key role in disease progression as it regulates almost all aspects of RNA processing, including RNA nuclear export, translation, splicing, and noncoding RNA processing. This review summarizes the mechanisms, molecular structures of RNA methylations and their roles in biological functions. Similar to the roles of RNA methylation in cancers, RNA methylation in RA and SLE involves "writers" that deposit methyl groups to form N6-methyladenosine (m6A) and 5-methylcytosine (m5C), "erasers" that remove these modifications, and "readers" that further affect mRNA splicing, export, translation, and degradation. Recent advances in detection methods have identified N1-methyladenosine (m1A), N6,2-O-dimethyladenosine (m6Am), and 7-methylguanosine (m7G) RNA modifications, and their roles in RA and SLE need to be further studied. The relationship between RNA methylation and other autoimmune diseases has not been reported, and the roles and mechanisms of RNA modifications in these diseases need to be explored in the future.
3. Ribosomal RNA 2'- O-methylations regulate translation by impacting ribosome dynamics
Sohail Khoshnevis, R Elizabeth Dreggors-Walker, Virginie Marchand, Yuri Motorin, Homa Ghalei Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2117334119. doi: 10.1073/pnas.2117334119. Epub 2022 Mar 16.
SignificanceThe presence of RNA chemical modifications has long been known, but their precise molecular consequences remain unknown. 2'-O-methylation is an abundant modification that exists in RNA in all domains of life. Ribosomal RNA (rRNA) represents a functionally important RNA that is heavily modified by 2'-O-methylations. Although abundant at functionally important regions of the rRNA, the contribution of 2'-O-methylations to ribosome activities is unknown. By establishing a method to disturb rRNA 2'-O-methylation patterns, we show that rRNA 2'-O-methylations affect the function and fidelity of the ribosome and change the balance between different ribosome conformational states. Our work links 2'-O-methylation to ribosome dynamics and defines a set of critical rRNA 2'-O-methylations required for ribosome biogenesis and others that are dispensable.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
