Mevastatin

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Mevastatin
Category Enzyme inhibitors
Catalog number BBF-01732
CAS 73573-88-3
Molecular Weight 390.51
Molecular Formula C23H34O5
Purity >98%

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Catalog Number Size Price Stock Quantity
BBF-01732 25 g $298 In stock

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Description

It is produced by the strain of Penicillum brevicompactum. It has weak anti-fungal activity and can inhibit the key enzyme (3-hydroxy-3-methyl glutaryl coenzyme A(HMGCoA) reductase) in the cholesterol biosynthesis pathway. It has been shown to lower cholesterol in animals and humans. It led the discovery of statins, lipid-lowering drugs. It is now used as a biochemical reagent.

Specification

Synonyms Mevastatina; Mevastatine; Mevastatinum; ML-236B; Compactin; CS-500; CS 500; CS500; ML-236B; ML 236B; ML236B; Antibiotic ML 236B
Storage -20 °C
IUPAC Name [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
Canonical SMILES CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
InChI InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChI Key AJLFOPYRIVGYMJ-INTXDZFKSA-N
Source Penicillium sp.

Properties

Appearance White to Off-White Solid
Application Hydroxymethylglutaryl-CoA Reductase Inhibitors
Antibiotic Activity Spectrum Fungi
Boiling Point 555.0±50.0 °C (Predicted)
Melting Point > 135 °C (dec.)
Density 1.13±0.1 g/cm3 (Predicted)
Solubility Soluble in Methanol, Acetone, Ethanol, DMF, DMSO

Reference Reading

1.Estimation of Antifungal Activity of Mevastatin Produced by Aspergillus terreus GCBL-03 on pretreated substrate in solid state fermentation.
Javed S1, Bukhari SA2, Ali M, Rehman SU. Curr Pharm Biotechnol. 2016;17(3):291-8.
This project was planned to study the production of cholesterol lowering drug mevastatin by Aspergillus terreus GCBL-03 on pretreated substrate bagasse in solid state fermentation. Bagasse was pretreated by potassium hydroxide to delignify the substrate to readily become available to microorganism. It was noticed that pretreated bagasse exhibited 13.69±0.64 mg/100mL yield of mevastatin and 6.63±0.48g dry cell mass as compared to nontreated substrate that showed 7.04±0.81 mg/100mL and 6.04±0.24g dry cell mass. The fermentation profile like pH (5.5), temperature (30°C), moisture contents (60%) inoculum size (2mL), and incubation time (72 h) showed the optimum production (30.63±1.24mg/100mL) of mevastatin. Furthermore, fermented drug showed noteworthy antifungal activity against battery of selected fungal strains assessed by disc diffusion and measurement of minimum inhibitory concentration by micro dilution method. It was concluded from the study that fermented mevastatin was effective against fungal strains.

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