MH-031
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03656 |
| CAS | 122246-01-9 |
| Molecular Weight | 156.14 |
| Molecular Formula | C7H8O4 |
Online Inquiry
Description
MH-031 is produced by the strain of Streptomyces rishiriensis A-5969 with protective effects on the liver.
Specification
| Synonyms | 3-(2-Oxo-2,5-dihydro-3-furanyl)propanoic acid; ACMC-20mpyj |
| IUPAC Name | 3-(5-oxo-2H-furan-4-yl)propanoic acid |
| Canonical SMILES | C1C=C(C(=O)O1)CCC(=O)O |
| InChI | InChI=1S/C7H8O4/c8-6(9)2-1-5-3-4-11-7(5)10/h3H,1-2,4H2,(H,8,9) |
| InChI Key | KCUAENDTKWKODS-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Acicular Crystal |
| Boiling Point | 411.1°C at 760 mmHg |
| Melting Point | 119-120°C |
| Density | 1.343 g/cm3 |
Reference Reading
1. Isolation and characterization of unusual hydrazides from Streptomyces sp. impact of the cultivation support and extraction procedure
Géraldine Le Goff, Marie-Thérèse Martin, Bogdan I Iorga, Emilie Adelin, Claudine Servy, Sylvie Cortial, Jamal Ouazzani J Nat Prod. 2013 Feb 22;76(2):142-9. doi: 10.1021/np300527p. Epub 2013 Feb 6.
Three novel hydrazides, geralcins C-E (1-3), were isolated from Streptomyces sp. LMA-545, together with MH-031 and geralcins A and B. This unusual family of compounds was isolated from liquid-state and agar-supported fermentation using Amberlite XAD-16 solid-phase extraction during the cultivation step. The use of such neutral resin during the cultivation step allowed the specific adsorption of microbial secondary metabolites, avoiding any contamination of the crude extracts by the constituents of the culture medium. The trapped compounds were eluted from the resin with methanol, and their structures elucidated using (1)H, (13)C, and (15)N NMR spectroscopic analysis and high-resolution mass spectrometry. Molecular modeling calculations were applied in order to support structural attributions. No antimicrobial, cytotoxic, or DnaG-inhibition activities were detected for geralcins D and E. Geralcin C has no antimicrobial activity but exhibited an IC(50) of 0.8 μM against KB and HCT116 cancer cell lines. Furthermore, geralcin C inhibited the E. coli DnaG primase, a Gram-negative antimicrobial target, with an IC(50) of 0.7 mM.
Recommended Products
| BBF-02642 | Lactonamycin | Inquiry |
| BBF-01693 | Doxorubicin EP Impurity A (Daunorubicin) | Inquiry |
| BBF-00764 | Cerebroside C | Inquiry |
| BBF-03753 | Baicalin | Inquiry |
| BBF-03755 | Actinomycin D | Inquiry |
| BBF-05862 | Epirubicin | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
