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Micafungin sodium

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Micafungin sodium
Category Enzyme inhibitors
Catalog number BBF-04053
CAS 208538-73-2
Molecular Weight 1292.25
Molecular Formula C56H70N9NaO23S
Purity >97%
Catalog Number Size Price Stock Quantity
BBF-04053 250 mg $469 In stock

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Micafungin Sodium is an inhibitor of 1,3-beta-D-glucan synthesis, used as an antifungal drug.

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Related CAS 235114-32-6 (free acid)
Synonyms FK463 Sodium; FK 463 Sodium; FK-463 Sodium; Mycamine; Funguard
Storage Store at -20°C
IUPAC Name sodium;[5-[(1S,2S)-2-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-[[4-[5-(4-pentoxyphenyl)-1,2-oxazol-3-yl]benzoyl]amino]-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl] sulfate
Canonical SMILES CCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC(=C(C=C7)O)OS(=O)(=O)[O-])O)O)C(CC(=O)N)O)C)O)O)O.[Na+]
InChI InChI=1S/C56H71N9O23S.Na/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76;/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85);/q;+1/p-1/t25-,26+,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+;/m0./s1
InChI Key KOOAFHGJVIVFMZ-WZPXRXMFSA-M
Appearance White to Off-white Solid
Antibiotic Activity Spectrum fungi
Melting Point >211°C
Solubility Soluble in ethanol, methanol, DMF, DMSO
1.Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant.
Piersigilli F1, Auriti C, Bersani I, Goffredo B, Bianco G, Savarese I, Dotta A. Pediatr Infect Dis J. 2014 Apr;33(4):419-20. doi: 10.1097/INF.0000000000000116.
So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol 70% and micafungin sodium 5 mg/L was added to the therapy, and blood cultures became sterile.
2.Comparison of the antifungal activity of micafungin and amphotericin B against Candida tropicalis biofilms.
Marcos-Zambrano LJ1, Escribano P2, Bouza E3, Guinea J4. J Antimicrob Chemother. 2016 May 4. pii: dkw162. [Epub ahead of print]
OBJECTIVES: Candida tropicalis is the fourth most common cause of candidaemia in hospitalized patients and associated mortality is high. C. tropicalis frequently causes biofilm-related infections. Echinocandins and amphotericin B show potent in vitro activity against C. albicans biofilms, but their activity against C. tropicalis biofilms has received little attention.
3.Prediction of micafungin area under the curve data by using peak concentration: applicability and utility in antifungal therapy
Srinivas NR1. Future Microbiol. 2016 Apr;11:485-90. doi: 10.2217/fmb.16.3. Epub 2016 Apr 12.
AIM: To describe a predictive model to obtain the area under the plasma concentration versus time curve (AUC) for micafungin to aid in dosing strategies in pediatric patients.
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