Milbemycin oxime
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Animal Health |
| Catalog number | BBF-03816 |
| CAS | 129496-10-2 |
| Molecular Weight | 2194.78 |
| Molecular Formula | C126H176N4O28 |
| Purity | ≥98% |
Ordering Information
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BBF-03816 | 500 mg | $439 | In stock | |
| BBF-03816 | 1 g | $523 | In stock | |
| BBF-03816 | 5 g | $998 | In stock |
Online Inquiry
Add to cartDescription
Milbemycin oxime is a semi-synthetic macrolide. As a nematocide and insecticide in veterinary medicine, it opens glutamate sensitive chloride channels in neurons of invertebrates that leads to paralysis by hyperpolarisation of these cells and signal transfer blocking. M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); Bile acid transporter: IC50 = 3.6 µM (human); TGR5: IC50 = 36.4 µM (human); HCT-116: IC50 >50 µM (human); GBM: IC50 >50 µM (human)
Specification
| Synonyms | Milbemycin A 5-oxime; Milbemite; Trifexis; Interceptor; Milbe Mite |
| Shelf Life | >2 years if stored properly |
| Storage | Store at -20°C, Under inert atmosphere |
| IUPAC Name | (1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21E,24S)-6'-ethyl-24-hydroxy-21-hydroxyimino-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one |
| Canonical SMILES | CCC1C(CCC2(O1)CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)C.CC1CCC2(CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)C)OC1C |
| InChI | InChI=1S/C32H45NO7.C31H43NO7/c1-6-27-21(4)12-13-31(40-27)17-25-16-24(39-31)11-10-20(3)14-19(2)8-7-9-23-18-37-29-28(33-36)22(5)15-26(30(34)38-25)32(23,29)35;1-18-7-6-8-23-17-36-28-27(32-35)21(4)14-26(31(23,28)34)29(33)37-25-15-24(10-9-19(2)13-18)39-30(16-25)12-11-20(3)22(5)38-30/h7-10,15,19,21,24-27,29,35-36H,6,11-14,16-18H2,1-5H3;6-9,14,18,20,22,24-26,28,34-35H,10-13,15-17H2,1-5H3 |
| InChI Key | CKVMAPHTVCTEMM-UHFFFAOYSA-N |
| Source | Semi-synthetic |
Properties
| Appearance | White Powder |
| Application | A broad spectrum insecticide; Used for treatment and prevention of heartworm in dogs and cats |
| Antibiotic Activity Spectrum | parasites |
| Melting Point | 169.6-177.4°C |
| Solubility | Soluble in DMSO, not in water |
Reference Reading
Recommended Products
| BBF-03754 | CASTANOSPERMINE | Inquiry |
| BBF-00764 | Cerebroside C | Inquiry |
| BBF-05862 | Epirubicin | Inquiry |
| BBF-01825 | Loganin | Inquiry |
| BBF-02614 | Nystatin | Inquiry |
| BBF-02642 | Lactonamycin | Inquiry |
Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
