MK800-62F1
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-03658 |
| CAS | |
| Molecular Weight | 606.83 |
| Molecular Formula | C35H58O8 |
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Description
MK800-62F1 is produced by the strain of Streptomyces diastochromogenes MK 800-62F1. It is used to inhibit H2O2-induced apoptosis in MS-1 cells (NCI-H) and Jurkat cells (TCL-H), and camptothecin-induced apoptosis in Jurkat cells.
Specification
| IUPAC Name | (2S,3R,4S,5S)-2-[[(3R,4S,4aR,6aS,6bR,9S,10S,12aR,14bS)-3,10-dihydroxy-9-(hydroxymethyl)-2,2,4a,6a,6b,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4-yl]oxy]oxane-3,4,5-triol |
| Canonical SMILES | CC1(CC2C3=CCC4C5(CCC(C(C5CCC4(C3(CCC2(C(C1O)OC6C(C(C(CO6)O)O)O)C)C)C)(C)CO)O)C)C |
| InChI | InChI=1S/C35H58O8/c1-30(2)16-20-19-8-9-23-32(4)12-11-24(38)33(5,18-36)22(32)10-13-35(23,7)34(19,6)15-14-31(20,3)28(27(30)41)43-29-26(40)25(39)21(37)17-42-29/h8,20-29,36-41H,9-18H2,1-7H3/t20-,21-,22?,23?,24-,25-,26+,27-,28+,29-,31+,32-,33+,34+,35+/m0/s1 |
| InChI Key | HRCPDUWVAPWYLU-IOMUPYOPSA-N |
Properties
| Appearance | White Powder |
| Boiling Point | 716.1±60.0°C at 760 mmHg |
| Melting Point | >200°C |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage
Nobutaka Morimoto, Masamitsu Shimazawa, Tetsumori Yamashima, Hiroichi Nagai, Hideaki Hara Brain Res. 2005 May 17;1044(1):8-15. doi: 10.1016/j.brainres.2005.02.062. Epub 2005 Apr 13.
The neuroprotective effects of minocycline-which is broadly protective in neurologic-disease models featuring cell death and is being evaluated in clinical trials-were investigated both in vitro and in vivo. For the in vivo study, focal cerebral ischemia was induced by permanent middle cerebral artery occlusion in mice. Minocycline at 90 mg/kg intraperitoneally administered 60 min before or 30 min after (but not 4 h after) the occlusion reduced infarction, brain swelling, and neurologic deficits at 24 h after the occlusion. For the in vitro studies, we used cortical-neuron cultures from rat fetuses in which neurotoxicity was induced by 24-h exposure to 500 microM glutamate. Furthermore, the effects of minocycline on oxidative stress [such as lipid peroxidation in mouse forebrain homogenates and free radical-scavenging activity against diphenyl-p-picrylhydrazyl (DPPH)] were evaluated to clarify the underlying mechanism. Minocycline significantly inhibited glutamate-induced cell death at 2 microM and lipid peroxidation and free radical scavenging at 0.2 and 2 microM, respectively. These findings indicate that minocycline has neuroprotective effects in vivo against permanent focal cerebral ischemia and in vitro against glutamate-induced cell death and that an inhibition of oxidative stress by minocycline may be partly responsible for these effects.
2. MK800-62F1, a new inhibitor of apoptotic cell death, from Streptomyces diastatochromogenes MK800-62F1. II. Structure elucidation
Y Yoshimoto, T Sawa, H Naganawa, T Sugai, T Takeuchi, M Imoto J Antibiot (Tokyo). 2000 Jun;53(6):575-8. doi: 10.7164/antibiotics.53.575.
A new compound, MK800-62F1, was isolated from a cultured broth of Streptomyces diastatochromogenes MK800-62F1. The structure was determined by NMR analysis and degradation experiments.
3. MK800-62F1, a new inhibitor of apoptotic cell death, from Streptomyces diastatochromogenes MK800-62F1. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity
Y Yoshimoto, T Sawa, N Kinoshita, Y Homma, M Hamada, T Takeuchi, M Imoto J Antibiot (Tokyo). 2000 Jun;53(6):569-74. doi: 10.7164/antibiotics.53.569.
A new compound, MK800-62F1, was isolated from a cultured broth of Streptomyces diastatochromogenes MK800-62F1. It inhibited H2O2-induced apoptosis in human small cell lung carcinoma Ms-1 cells as well as in human T-cell leukemia Jurkat cells. In addition, MK800-62F1 also inhibited camptothecin-induced apoptosis in Jurkat cells, which was mediated by intracellular H2O2 generation. MK800-62F1 did not exhibit antioxidative activity in vitro, suggesting that inhibition of apoptosis by MK800-62F1 was not due to the scavenging of H2O2, rather it was due to the modulation of the downstream event of H2O2 generation.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
