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Monamycin E

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category Antibiotics
Catalog number BBF-01957
CAS 31871-62-2
Molecular Weight 705.88
Molecular Formula C35H59N7O8

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Monamycin E is an ester peptide antibiotic produced by Str. jamaicensis A-154. Activity against gram-positive bacteria.

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Storage Store at -20°C
IUPAC Name 20,23-di(butan-2-yl)-6-hydroxy-10,15-dimethyl-11-(2-methylpropyl)-22-oxa-3,4,10,13,19,25,26-heptazatetracyclo[23.4.0.03,8.013,17]nonacosane-2,9,12,18,21,24-hexone
Canonical SMILES CCC(C)C1C(=O)OC(C(=O)N2C(CCCN2)C(=O)N3C(CC(CN3)O)C(=O)N(C(C(=O)N4CC(CC4C(=O)N1)C)CC(C)C)C)C(C)CC
InChI InChI=1S/C35H59N7O8/c1-9-21(6)28-35(49)50-29(22(7)10-2)34(48)41-24(12-11-13-36-41)33(47)42-27(16-23(43)17-37-42)31(45)39(8)26(14-19(3)4)32(46)40-18-20(5)15-25(40)30(44)38-28/h19-29,36-37,43H,9-18H2,1-8H3,(H,38,44)
InChI Key WJSQTHMNLYUAQI-UHFFFAOYSA-N
Appearance Crystal
Antibiotic Activity Spectrum Gram-positive bacteria
Melting Point 116-118°C
Solubility Soluble in Methanol, Chloroform
1. Manumycins E, F and G, new members of manumycin class antibiotics, from Streptomyces sp
Y Z Shu, S Huang, R R Wang, K S Lam, S E Klohr, K J Volk, D M Pirnik, J S Wells, P B Fernandes, P S Patel J Antibiot (Tokyo). 1994 Mar;47(3):324-33. doi: 10.7164/antibiotics.47.324.
Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.
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