Monamycin E
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| Category | Antibiotics |
| Catalog number | BBF-01957 |
| CAS | 31871-62-2 |
| Molecular Weight | 705.88 |
| Molecular Formula | C35H59N7O8 |
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Description
Monamycin E is an ester peptide antibiotic produced by Str. jamaicensis A-154. Activity against gram-positive bacteria.
Specification
| Storage | Store at -20°C |
| IUPAC Name | 20,23-di(butan-2-yl)-6-hydroxy-10,15-dimethyl-11-(2-methylpropyl)-22-oxa-3,4,10,13,19,25,26-heptazatetracyclo[23.4.0.03,8.013,17]nonacosane-2,9,12,18,21,24-hexone |
| Canonical SMILES | CCC(C)C1C(=O)OC(C(=O)N2C(CCCN2)C(=O)N3C(CC(CN3)O)C(=O)N(C(C(=O)N4CC(CC4C(=O)N1)C)CC(C)C)C)C(C)CC |
| InChI | InChI=1S/C35H59N7O8/c1-9-21(6)28-35(49)50-29(22(7)10-2)34(48)41-24(12-11-13-36-41)33(47)42-27(16-23(43)17-37-42)31(45)39(8)26(14-19(3)4)32(46)40-18-20(5)15-25(40)30(44)38-28/h19-29,36-37,43H,9-18H2,1-8H3,(H,38,44) |
| InChI Key | WJSQTHMNLYUAQI-UHFFFAOYSA-N |
Properties
| Appearance | Crystal |
| Antibiotic Activity Spectrum | Gram-positive bacteria |
| Melting Point | 116-118°C |
| Solubility | Soluble in Methanol, Chloroform |
Reference Reading
1. Manumycins E, F and G, new members of manumycin class antibiotics, from Streptomyces sp
Y Z Shu, S Huang, R R Wang, K S Lam, S E Klohr, K J Volk, D M Pirnik, J S Wells, P B Fernandes, P S Patel J Antibiot (Tokyo). 1994 Mar;47(3):324-33. doi: 10.7164/antibiotics.47.324.
Three new manumycin class antibiotics, namely manumycins E, F and G, were isolated from the culture broth of Streptomyces sp. strain WB-8376. Their structures were established by spectroscopic methods, and the S configuration of C-4 in the epoxycyclohexenone moiety was determined by CD exciton chirality method for each of the three compounds. Manumycins E, F and G are active against Gram-positive bacteria, and have moderate inhibitory effects on the farnesylation of p21 ras protein. They demonstrated weak cytotoxic activity against human colon tumor cell HCT-116.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
