Morantel (+)-tartrate salt
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| Category | Others |
| Catalog number | BBF-03808 |
| CAS | 26155-31-7 |
| Molecular Weight | 370.42 |
| Molecular Formula | C16H22N2O6S |
| Purity | >98% |
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Description
Morantel tartrate, the 3-methyl thiophene tartrate salt analog of pyrantel tartrate, is a low toxic broad spectrum anthelmintic that is effective against the immature and adult stages of certain species of nematodes.
Specification
| Related CAS | 20574-50-9 (free acid) |
| Synonyms | 2,3-dihydroxybutanedioic acid |
| Shelf Life | 2 years |
| Storage | Store at -20°C |
| IUPAC Name | 2,3-dihydroxybutanedioic acid;1-methyl-2-[(E)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4H-pyrimidine |
| Canonical SMILES | CC1=C(SC=C1)C=CC2=NCCCN2C.C(C(C(=O)O)O)(C(=O)O)O |
| InChI | InChI=1S/C12H16N2S.C4H6O6/c1-10-6-9-15-11(10)4-5-12-13-7-3-8-14(12)2;5-1(3(7)8)2(6)4(9)10/h4-6,9H,3,7-8H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/b5-4+; |
| InChI Key | GGXQONWGCAQGNA-FXRZFVDSSA-N |
Properties
| Appearance | White to Off-white Crystalline Powder |
| Antibiotic Activity Spectrum | parasites |
| Boiling Point | 334.6°C at 760 mmHg |
| Solubility | Soluble in Water |
Reference Reading
1.The effect of route of administration on the anthelmintic efficacy of benzimidazole anthelmintics in sheep infected with strains of Haemonchus contortus and Trichostrongylus colubriformis resistant or susceptible to thiabendazole.
Kelly JD;Hall CA;Whitlock HV;Thompson HG;Campbell NJ;Martin IC Res Vet Sci. 1977 Mar;22(2):161-8.
Observations of erratic anthelmintic activity of fenbendazole against known standardised thiabendazole-resistant strains of Haemonchus contortus and Trichostrongylus colubriformis in sheep were investigated. Fenbendazole at a dose rate of 10 mg/kg body weight was administered by oral, intra-ruminal or intra-abomasal routes, and was most effective against both resistant strains following intra-ruminal administration. In addition thiabendazole, oxibendazole, fenbendazole, parbendazole and mebendazole plus two unrelated compounds, levamisole and morantel tartrate, were used at one and a half times their suggested or recommended therapeutic dose rate against thiabendazole-resistant strains of H contortus and T colubriformis in sheep; each drug being administered by the intra-ruminal or intra-abomasal routes. Fenbendazole was more effective against both strains following intra-ruminal administration. Parbendazole was more effective against the resistant strain of T colubriformis following intra-ruminal administration. At the dose rate chosen for the other benzimidazoles used against these resistant strains, there was no difference in anthelmintic efficacy due to route of administration. Levamisole was highly effective against both resistant strains, irrespective of the route of administration.
2.Benzimidazole resistance in small strongyles of horses.
Barger IA;Lisle KA Aust Vet J. 1979 Dec;55(12):594-5.
Treatments with mebendazole, cambendazole or febantel were ineffective in reducing the faecal egg count of a group of 40 horses infected with small strongyle species. Evidence was also obtained that this apparent resistance extended to fenbendazole. In horses dosed with morantel tartrate egg counts were reduced to zero by 7 days after treatment. The development of resistance is discussed in relation to previous treatment of the horses and the mode of action of febantel.
3.Trichostrongylus colubriformis and Ostertagia sp resistant to levamisole, morantel tartrate and thiabendazole: isolation into pure strain and anthelmintic titration.
Whitlock HV;Sangster NC;Gunawan M;Porter CJ;Kelly JD Res Vet Sci. 1980 Jul;29(1):31-5.
Strains of Trichostrongylus colubriformis (designated PF4) and Ostertagia sp (O circumcincta/O trifurcata, designated PF5), with varying degrees of resistance to levamisole, morantel tartrate and thiabendazole were isolated into pure culture. Detailed dose response studies showed that both T colubriformis and Ostertagia sp were highly resistant to levamisole and morantel with low level resistance to thiabendazole. The effective dose required to remove 80 per cent worm burdens (ED80) was calculated for each anthelmintic. For T colubriformis the ED80 for levamisole and thiabendazole were 12.6 and 40.1 mg/kg respectively. For Ostertagia sp, the ED80 for levamisole, thiabendazole and morantel were 20.4, 45.2 and 35.8 mg/kg respectively. The implications of these results are discussed with reference to alternative means of chemical control.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
