Mycotrienol I
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| Category | Bioactive by-products |
| Catalog number | BBF-01976 |
| CAS | 81904-15-6 |
| Molecular Weight | 455.54 |
| Molecular Formula | C26H33NO6 |
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Description
Mycotrienol I is a polyene macrolide compound produced by Str. rishiriensis T-23. It has anti-fungal and anti-leukemia activity.
Specification
| Synonyms | Ansatrienol A; (4E,6S,7S,8R,10E,12E,14E,16R)-6,8-dihydroxy-16-methoxy-5,7-dimethyl-19-azabicyclo[18.3.1]tetracosa-1(23),4,10,12,14,20-hexaene-18,22,24-trione |
| Storage | Store at -20°C |
| IUPAC Name | (5R,6E,8E,10E,13R,14S,15S,16E)-13,15-dihydroxy-5-methoxy-14,16-dimethyl-2-azabicyclo[18.3.1]tetracosa-1(23),6,8,10,16,20-hexaene-3,22,24-trione |
| Canonical SMILES | CC1C(CC=CC=CC=CC(CC(=O)NC2=CC(=O)C=C(C2=O)CCC=C(C1O)C)OC)O |
| InChI | InChI=1S/C26H33NO6/c1-17-10-9-11-19-14-20(28)15-22(26(19)32)27-24(30)16-21(33-3)12-7-5-4-6-8-13-23(29)18(2)25(17)31/h4-8,10,12,14-15,18,21,23,25,29,31H,9,11,13,16H2,1-3H3,(H,27,30)/b5-4+,8-6+,12-7+,17-10+/t18-,21-,23+,25+/m0/s1 |
| InChI Key | KDVQXJCAPWJRKD-VWMGDPEBSA-N |
Properties
| Appearance | Yellow Powder |
| Antibiotic Activity Spectrum | fungi |
| Boiling Point | 710.1±60.0°C at 760 mmHg |
| Melting Point | 94-95°C |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in Methanol, Chloroform, Ethyl acetate |
Reference Reading
1. Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols
M Kuwano, K Ikezaki, K Mamizuka, S Komiyama, H Seto, N Otake, M Sugita, T Yamaguchi, T Kishiye, H Fukawa, et al. Gan. 1983 Oct;74(5):759-66.
Mycotrienins I and II and mycotrienols I and II are ansamycin antibiotics containing a triene structure, isolated from Streptomyces rishiriensis. An amphotericin B-resistant clone (AMBR-1) derived from cultured Chinese hamster V79 cells was cross-resistant to mycotrienins I and II, but not to mycotrienol I or II. These four ansamycin antibiotics were found to potentiate significantly the action of some anti-cancer agents including 5-fluorouracil, cis-diamminedichloroplatinum, bleomycin, mitomycin C and 6-mercaptopurine against cultured V79 cells. The action of adriamycin was not potentiated. These four ansamycin antibiotics showed a synergism spectrum similar to that of smaller polyene antibiotics.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
