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Mycotrienol II

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Mycotrienol II
Category Bioactive by-products
Catalog number BBF-01977
CAS 84906-73-0
Molecular Weight 457.56
Molecular Formula C26H35NO6

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Mycotrienol II is a polyene macrolide compound produced by Str. rishiriensis T-23. It has anti-fungal and anti-leukemia activity.

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Synonyms 20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A; Ansatrienol A, 20,23-didehydro-20,23-dideoxo-20,23-dihydroxy-
IUPAC Name (5R,6Z,8Z,10Z,13S,14S,15R,16Z)-13,15,22,24-tetrahydroxy-5-methoxy-14,16-dimethyl-2-azabicyclo[18.3.1]tetracosa-1(23),6,8,10,16,20(24),21-heptaen-3-one
Canonical SMILES CC1C(CC=CC=CC=CC(CC(=O)NC2=CC(=CC(=C2O)CCC=C(C1O)C)O)OC)O
InChI InChI=1S/C26H35NO6/c1-17-10-9-11-19-14-20(28)15-22(26(19)32)27-24(30)16-21(33-3)12-7-5-4-6-8-13-23(29)18(2)25(17)31/h4-8,10,12,14-15,18,21,23,25,28-29,31-32H,9,11,13,16H2,1-3H3,(H,27,30)/b5-4-,8-6-,12-7-,17-10-/t18-,21-,23-,25-/m0/s1
InChI Key WXMPIECSLUKADI-UEHQEYCJSA-N
Appearance White Powder
Antibiotic Activity Spectrum fungi
Boiling Point 696.1±55.0°C at 760 mmHg
Melting Point 130-132°C
Density 1.2±0.1 g/cm3
1. Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols
M Kuwano, K Ikezaki, K Mamizuka, S Komiyama, H Seto, N Otake, M Sugita, T Yamaguchi, T Kishiye, H Fukawa, et al. Gan. 1983 Oct;74(5):759-66.
Mycotrienins I and II and mycotrienols I and II are ansamycin antibiotics containing a triene structure, isolated from Streptomyces rishiriensis. An amphotericin B-resistant clone (AMBR-1) derived from cultured Chinese hamster V79 cells was cross-resistant to mycotrienins I and II, but not to mycotrienol I or II. These four ansamycin antibiotics were found to potentiate significantly the action of some anti-cancer agents including 5-fluorouracil, cis-diamminedichloroplatinum, bleomycin, mitomycin C and 6-mercaptopurine against cultured V79 cells. The action of adriamycin was not potentiated. These four ansamycin antibiotics showed a synergism spectrum similar to that of smaller polyene antibiotics.

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