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N-(2,6-Diamino-6-hydroxymethylpimelyl)-L-alanine

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Category Antibiotics
Catalog number BBF-01374
CAS 77625-76-4
Molecular Weight 291.30
Molecular Formula C11H21N3O6

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

N-(2,6-Diamino-6-hydroxymethylpimelyl)-L-alanine is produced by the strain of Micromonspora chalcea PA3534. On the synthetic medium, it showed anti-Escherichia coli activity, and was combined with several cell wall synthesis inhibitors such as fosfomycin, cycloserine, penicillin, and cephalosporin, the combination of sporozoin has obvious synergistic antibacterial effect.

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Synonyms Antibiotic PA 3534J; N-(2,6-Diamino-6-hydroxymethylpimelyl)alanine; 7-((1-Carboxyethyl)amino)-2,6-diamino-2-(hydroxymethyl)-7-oxoheptanoic acid
IUPAC Name 2,6-diamino-7-(1-carboxyethylamino)-2-(hydroxymethyl)-7-oxoheptanoic acid
Canonical SMILES CC(C(=O)O)NC(=O)C(CCCC(CO)(C(=O)O)N)N
InChI InChI=1S/C11H21N3O6/c1-6(9(17)18)14-8(16)7(12)3-2-4-11(13,5-15)10(19)20/h6-7,15H,2-5,12-13H2,1H3,(H,14,16)(H,17,18)(H,19,20)
InChI Key FMWUTCUMQJNBJE-UHFFFAOYSA-N
Antibiotic Activity Spectrum fungi
1. Isolation of N-(2,6-diamino-6-hydroxymethylpimelyl)-L-alanine from Micromonospora chalcea
J Shoji, H Hinoo, T Kato, K Nakauchi, S Matsuura, M Mayama, Y Yasuda, Y Kawamura J Antibiot (Tokyo). 1981 Apr;34(4):374-80. doi: 10.7164/antibiotics.34.374.
A novel dipeptide, N-(2,6-diamino-6-hydroxymethylpimelyl)-L-alanine, was isolated from the culture broth of a microorganism identified as Micromonospora chalcea. The dipeptide exhibits antimicrobial activity against Escherichia coli on a synthetic medium, and the activity is synergistically enhanced by several cell wall synthesis-inhibitors.

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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