N-(2,6-Diamino-6-hydroxymethylpimelyl)-L-alanine

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Category Antibiotics
Catalog number BBF-01374
CAS 77625-76-4
Molecular Weight 291.30
Molecular Formula C11H21N3O6

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Description

N-(2,6-Diamino-6-hydroxymethylpimelyl)-L-alanine is produced by the strain of Micromonspora chalcea PA3534. On the synthetic medium, it showed anti-Escherichia coli activity, and was combined with several cell wall synthesis inhibitors such as fosfomycin, cycloserine, penicillin, and cephalosporin, the combination of sporozoin has obvious synergistic antibacterial effect.

Specification

Synonyms Antibiotic PA 3534J; N-(2,6-Diamino-6-hydroxymethylpimelyl)alanine; 7-((1-Carboxyethyl)amino)-2,6-diamino-2-(hydroxymethyl)-7-oxoheptanoic acid
IUPAC Name 2,6-diamino-7-(1-carboxyethylamino)-2-(hydroxymethyl)-7-oxoheptanoic acid
Canonical SMILES CC(C(=O)O)NC(=O)C(CCCC(CO)(C(=O)O)N)N
InChI InChI=1S/C11H21N3O6/c1-6(9(17)18)14-8(16)7(12)3-2-4-11(13,5-15)10(19)20/h6-7,15H,2-5,12-13H2,1H3,(H,14,16)(H,17,18)(H,19,20)
InChI Key FMWUTCUMQJNBJE-UHFFFAOYSA-N

Properties

Antibiotic Activity Spectrum fungi

Reference Reading

1. Isolation of N-(2,6-diamino-6-hydroxymethylpimelyl)-L-alanine from Micromonospora chalcea
J Shoji, H Hinoo, T Kato, K Nakauchi, S Matsuura, M Mayama, Y Yasuda, Y Kawamura J Antibiot (Tokyo). 1981 Apr;34(4):374-80. doi: 10.7164/antibiotics.34.374.
A novel dipeptide, N-(2,6-diamino-6-hydroxymethylpimelyl)-L-alanine, was isolated from the culture broth of a microorganism identified as Micromonospora chalcea. The dipeptide exhibits antimicrobial activity against Escherichia coli on a synthetic medium, and the activity is synergistically enhanced by several cell wall synthesis-inhibitors.

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