N-Acetyl-D-glutamine
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| Category | Others |
| Catalog number | BBF-05690 |
| CAS | 161579-61-9 |
| Molecular Weight | 188.18 |
| Molecular Formula | C7H12N2O4 |
| Purity | ≥95% by HPLC |
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Description
N-Acetyl-D-glutamine is a pivotal biomedical formulation, serving as a crucial precursor to the vital antioxidant glutathione. It efficaciously aids in the research of hepatic disorders, immune system dysregulation and afflictions pertaining to the gastrointestinal tract.
Specification
| Synonyms | Ac-D-Gln-OH; N(2)-acetyl-D-glutamine; (R)-2-Acetamido-5-amino-5-oxopentanoic acid; acetyl-D-glutamine; acetyl-D-glutamine |
| Storage | Store at -20°C |
| IUPAC Name | (2R)-2-acetamido-5-amino-5-oxopentanoic acid |
| Canonical SMILES | CC(=O)NC(CCC(=O)N)C(=O)O |
| InChI | InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m1/s1 |
| InChI Key | KSMRODHGGIIXDV-RXMQYKEDSA-N |
Properties
| Appearance | White to Off-white Solid |
| Boiling Point | 604.9±50.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
Reference Reading
1. Enantioseparation of N-acetyl-glutamine enantiomers by LC-MS/MS and its application to a plasma protein binding study
Lei Gao, Yunwen Xue, Zunjian Zhang, Yuan Tian Biomed Chromatogr . 2019 Sep;33(9):e4559. doi: 10.1002/bmc.4559.
A novel chiral method was developed and validated to determine N-acetyl-glutamine (NAG) enantiomers by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Enantioseparation was achieved on a Chiralpak QD-AX column (150 × 4.6 mm i.d., 5 μm) using methanol-water (50 mm ammonium formate, pH 4.3; 70:30, v/v) at a flow rate of 500 μL/min. The detection was operated with an electrospray ionization source interface in positive mode. The ion transition for NAG enantiomers was m/z 189.0 → 130.0. The retention time of N-acetyl-l-glutamine and N-acetyl-d-glutamine were 15.2 and 17.0 min, respectively. Calibration curves were linear over the range of 0.02-20 μg/mL with r > 0.99. The deviation of accuracy and the coefficient of variation of within-run and between-run precision were within 10% for both enantiomers, except for the lower limit of quantification (20 ng/mL), where they deviated 88% and no obvious matrix effect was observed. This method was successfully applied to investigate the plasma protein binding of NAG enantiomers in rats. The results showed that the plasma protein binding of NAG enantiomers was stereoselective. The assay method also exhibited good application prospects for the clinical monitoring of free drugs in plasma.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
