N-Methylstreptothricin F

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Category Antibiotics
Catalog number BBF-03143
CAS 99237-10-2
Molecular Weight 516.55
Molecular Formula C20H36N8O8
Purity >98%

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Description

N-Methylstreptothricin F is a streptomycin antibiotic produced by Actinomyces sp. A37812. It has good antibacterial activity against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae.

Specification

Synonyms A 37812
Storage Store at -20°C
IUPAC Name [5-(3,6-diaminohexanoylamino)-4-hydroxy-2-(hydroxymethyl)-6-[(7-hydroxy-5-methyl-4-oxo-3a,6,7,7a-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)amino]oxan-3-yl] carbamate
Canonical SMILES CN1CC(C2C(C1=O)N=C(N2)NC3C(C(C(C(O3)CO)OC(=O)N)O)NC(=O)CC(CCCN)N)O
InChI InChI=1S/C20H36N8O8/c1-28-6-9(30)12-13(18(28)33)26-20(25-12)27-17-14(24-11(31)5-8(22)3-2-4-21)15(32)16(36-19(23)34)10(7-29)35-17/h8-10,12-17,29-30,32H,2-7,21-22H2,1H3,(H2,23,34)(H,24,31)(H2,25,26,27)
InChI Key NTYMNKDOXUGECC-UHFFFAOYSA-N

Properties

Appearance Solid Powder
Antibiotic Activity Spectrum Gram-positive bacteria; Gram-negative bacteria
Density 1.81 g/cm3
Solubility Soluble in DMSO

Reference Reading

1. A37812: N-methylstreptothricin F
A H Hunt, R L Hamill, J R DeBoer, E A Presti J Antibiot (Tokyo). 1985 Aug;38(8):987-92. doi: 10.7164/antibiotics.38.987.
A37812, a new member of the streptothricin class of antibiotics, has been isolated and characterized as N-methylstreptothricin F. The structure elucidation of A37812 is based on results from 13C and 1H NMR spectroscopies.

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