Napyradiomycin C2
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| Category | Antibiotics |
| Catalog number | BBF-01995 |
| CAS | 103106-19-0 |
| Molecular Weight | 513.84 |
| Molecular Formula | C25H27Cl3O5 |
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Description
Napyradiomycin C2 is an antibiotic produced by Chainia rubra MG802-AF1. It has anti-gram-positive bacteria and mycobacterial activity.
Specification
| Synonyms | 7,18a-Methano-6,10-metheno-5H-cyclohexadeca(b)pyran-5,19-dione, 3,4a,13-trichloro-2,3,4,4a,11,12,13,14,15,18-decahydro-9,20-dihydroxy-2,2,16-trimethyl-12-methylene- |
| Storage | Store at -20°C |
| IUPAC Name | (3E)-7,16,18-trichloro-11,22-dihydroxy-4,19,19-trimethyl-8-methylidene-20-oxatetracyclo[11.7.1.110,14.01,16]docosa-3,10,12,14(22)-tetraene-15,21-dione |
| Canonical SMILES | CC1=CCC23C(=O)C4=CC(=C(CC(=C)C(CC1)Cl)C(=C4C(=O)C2(CC(C(O3)(C)C)Cl)Cl)O)O |
| InChI | InChI=1S/C25H27Cl3O5/c1-12-5-6-16(26)13(2)9-14-17(29)10-15-19(20(14)30)22(32)24(28)11-18(27)23(3,4)33-25(24,8-7-12)21(15)31/h7,10,16,18,29-30H,2,5-6,8-9,11H2,1,3-4H3/b12-7+ |
| InChI Key | TUASWIIAAPWHMO-KPKJPENVSA-N |
Properties
| Appearance | Yellow Brown Powder |
| Antibiotic Activity Spectrum | Gram-positive bacteria; mycobacteria |
| Boiling Point | 714.3°C at 760 mmHg |
| Melting Point | 81-90°C |
| Density | 1.42 g/cm3 |
| Solubility | Soluble in Methanol, Chloroform |
Reference Reading
1. Biosynthesis of napyradiomycins
K Shiomi, H Iinuma, H Naganawa, K Isshiki, T Takeuchi, H Umezawa J Antibiot (Tokyo). 1987 Dec;40(12):1740-5. doi: 10.7164/antibiotics.40.1740.
Biosynthetic studies on napyradiomycins were carried out based on the incorporation of [2-13C]acetate and [1,2-13C]acetate. The alignment of acetate units suggested that the B and C rings of napyradiomycins are derived from a pentaketide, while ring A and the side chain may be synthesized from mevalonate.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
