Nemotin
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Antibiotics |
| Catalog number | BBF-02109 |
| CAS | 502-12-5 |
| Molecular Weight | 172.18 |
| Molecular Formula | C11H8O2 |
| Purity | 98% |
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Description
It is produced by the strain of Poria corticola B-841, 71280. Nemotin has the activity against gram-positive bacteria, mycobacterium and fungus, and also against gram-negative bacteria, but the activity is weak.
Specification
| Synonyms | BRN 0125855; 5-(1,2-Heptadiene-4,6-diynyl)dihydro-2(3H)-furanone; 5-(Hepta-1,2-diene-4,6-diyn-1-yl)oxolan-2-one |
| Canonical SMILES | C#CC#CC=C=CC1CCC(=O)O1 |
| InChI | InChI=1S/C11H8O2/c1-2-3-4-5-6-7-10-8-9-11(12)13-10/h1,5,7,10H,8-9H2 |
| InChI Key | FRTIRZDYHKNXHV-UHFFFAOYSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria; mycobacteria; fungi |
| Boiling Point | 347.3°C at 760 mmHg |
| Density | 1.196 g/cm3 |
Reference Reading
1. Beyond acute cholecystitis-gallstone-related complications and what the emergency radiologist should know
Andrew Tran, Carrie Hoff, Karunesh Polireddy, Arie Neymotin, Kiran Maddu Emerg Radiol. 2022 Feb;29(1):173-186. doi: 10.1007/s10140-021-01999-y. Epub 2021 Nov 17.
The purpose of this study is to emphasize the imaging features of complications of gallstones beyond the cystic duct on ultrasound (US), enhanced and nonenhanced computed tomography (CECT and NECT), magnetic resonance imaging (MRI), magnetic resonance cholangiopancreatography (MRCP), and endoscopic retrograde cholangiopancreatography (ERCP). This article includes a brief overview of gallstone imaging and emerging trends in the detection of gallstones. This review article will highlight complications of gallstones, including choledocholithiasis, gallstone pancreatitis, acute cholangitis, Mirizzi syndrome, cholecystobiliary and cholecystoenteric fistulas, and gallstone ileus. Imaging findings and limitations of US, CT, MRI, and ERCP will be discussed. The review article will also briefly discuss the management of each disease. The presence of gallstones beyond the level of the cystic duct can lead to a spectrum of diseases, and emergency radiologists play a critical role in disease management by providing a timely diagnosis. Documenting the location of a gallstone within the common bile duct (CBD) in symptomatic cholelithiasis and the presence of acute interstitial edematous pancreatitis and/or ascending cholangitis plays a pivotal role in disease management. Establishing the presence of ectopic gallstones and biliary-enteric fistulae has a significant role in directing patient management.
2. Detecting Spontaneous Neural Oscillation Events in Primate Auditory Cortex
Samuel A Neymotin, Idan Tal, Annamaria Barczak, Monica N O'Connell, Tammy McGinnis, Noah Markowitz, Elizabeth Espinal, Erica Griffith, Haroon Anwar, Salvador Dura-Bernal, Charles E Schroeder, William W Lytton, Stephanie R Jones, Stephan Bickel, Peter Lakatos eNeuro. 2022 Aug 19;9(4):ENEURO.0281-21.2022. doi: 10.1523/ENEURO.0281-21.2022. Print 2022 Jul-Aug.
Electrophysiological oscillations in the brain have been shown to occur as multicycle events, with onset and offset dependent on behavioral and cognitive state. To provide a baseline for state-related and task-related events, we quantified oscillation features in resting-state recordings. We developed an open-source wavelet-based tool to detect and characterize such oscillation events (OEvents) and exemplify the use of this tool in both simulations and two invasively-recorded electrophysiology datasets: one from human, and one from nonhuman primate (NHP) auditory system. After removing incidentally occurring event-related potentials (ERPs), we used OEvents to quantify oscillation features. We identified ~2 million oscillation events, classified within traditional frequency bands: δ, θ, α, β, low γ, γ, and high γ. Oscillation events of 1-44 cycles could be identified in at least one frequency band 90% of the time in human and NHP recordings. Individual oscillation events were characterized by nonconstant frequency and amplitude. This result necessarily contrasts with prior studies which assumed frequency constancy, but is consistent with evidence from event-associated oscillations. We measured oscillation event duration, frequency span, and waveform shape. Oscillations tended to exhibit multiple cycles per event, verifiable by comparing filtered to unfiltered waveforms. In addition to the clear intraevent rhythmicity, there was also evidence of interevent rhythmicity within bands, demonstrated by finding that coefficient of variation of interval distributions and Fano factor (FF) measures differed significantly from a Poisson distribution assumption. Overall, our study provides an easy-to-use tool to study oscillation events at the single-trial level or in ongoing recordings, and demonstrates that rhythmic, multicycle oscillation events dominate auditory cortical dynamics.
3. Oscillatory Bursting as a Mechanism for Temporal Coupling and Information Coding
Idan Tal, Samuel Neymotin, Stephan Bickel, Peter Lakatos, Charles E Schroeder Front Comput Neurosci. 2020 Sep 15;14:82. doi: 10.3389/fncom.2020.00082. eCollection 2020.
Even the simplest cognitive processes involve interactions between cortical regions. To study these processes, we usually rely on averaging across several repetitions of a task or across long segments of data to reach a statistically valid conclusion. Neuronal oscillations reflect synchronized excitability fluctuations in ensembles of neurons and can be observed in electrophysiological recordings in the presence or absence of an external stimulus. Oscillatory brain activity has been viewed as sustained increase in power at specific frequency bands. However, this perspective has been challenged in recent years by the notion that oscillations may occur as transient burst-like events that occur in individual trials and may only appear as sustained activity when multiple trials are averaged together. In this review, we examine the idea that oscillatory activity can manifest as a transient burst as well as a sustained increase in power. We discuss the technical challenges involved in the detection and characterization of transient events at the single trial level, the mechanisms that might generate them and the features that can be extracted from these events to study single-trial dynamics of neuronal ensemble activity.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
