Neosordarin
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| Category | Antibiotics |
| Catalog number | BBF-02118 |
| CAS | |
| Molecular Weight | 658.77 |
| Molecular Formula | C36H50O11 |
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Description
Neosordarin is originally isolated from Sordaria araneosa Cain. Neosordarin has antifungal activity and inhibits S. Cerevisia with the IC50 of 0.2-0.3 μg/mL.
Specification
| IUPAC Name | (1R,2S,4R,5R,8R,9S,11R)-9-formyl-2-[[(2R,3S,4S,5R,6R)-3-hydroxy-4-[(2E,5E)-7-hydroxy-2-methyl-4-oxoocta-2,5-dienoyl]oxy-5-methoxy-6-methyloxan-2-yl]oxymethyl]-5-methyl-13-propan-2-yltetracyclo[7.4.0.02,11.04,8]tridec-12-ene-1-carboxylic acid |
| Canonical SMILES | CC1CCC2C1CC3(C4CC2(C3(C(=C4)C(C)C)C(=O)O)C=O)COC5C(C(C(C(O5)C)OC)OC(=O)C(=CC(=O)C=CC(C)O)C)O |
| InChI | InChI=1S/C36H50O11/c1-18(2)27-13-23-14-34(16-37)26-11-8-19(3)25(26)15-35(23,36(27,34)33(42)43)17-45-32-28(40)30(29(44-7)22(6)46-32)47-31(41)20(4)12-24(39)10-9-21(5)38/h9-10,12-13,16,18-19,21-23,25-26,28-30,32,38,40H,8,11,14-15,17H2,1-7H3,(H,42,43)/b10-9+,20-12+/t19-,21?,22-,23+,25-,26-,28+,29-,30+,32-,34+,35+,36+/m1/s1 |
| InChI Key | ZYLVYEPSNXRLDN-UPTYFVEISA-N |
Properties
| Appearance | White Powder |
| Antibiotic Activity Spectrum | fungi |
| Melting Point | 53-57°C |
Reference Reading
1. Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa
Paolo Davoli, Günther Engel, Andreas Werle, Olov Sterner, Timm Anke J Antibiot (Tokyo). 2002 Apr;55(4):377-82. doi: 10.7164/antibiotics.55.377.
Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose moiety. Hydroxysordarin (3) closely resembles sordarin (4), the only slight difference being the replacement of sordarose with altrose as the sugar unit.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
