(-)-Neplanocin A

(-)-Neplanocin A

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It is produced by the strain of Nocardia sp. C-15003(N-1). It has the function of anti-tumor, anti-plant pathogenic fungi, skin fungi and protozoa, and has no antibacterial activity.

(-)-Neplanocin A
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Catalog Number BBF-02600
CAS 72877-50-0
Description (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).
Molecular Formula C11H13N5O3
Molecular Weight 263.25
Antibiotic Activity Spectrum neoplastics (Tumor); fungi; viruses
Synonyms NPC-A; (-)-9-(trans-2,trans-3-Dihydroxy-4-(hydroxymethyl)-cyclopent-4-enyl)-adenine; 5-(6-Amino-purin-9-yl)-3-hydroxymethyl-cyclopent-3-ene-1,2-diol
IUPAC Name (1S,2R,5R)-5-(6-aminopurin-9-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
Canonical SMILES C1=C(C(C(C1N2C=NC3=C(N=CN=C32)N)O)O)CO
InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1
Boiling Point 632.6±65.0°C at 760 mmHg
Melting Point 220-227°C
Purity ≥98%
Density 1.9±0.1 g/cm3
Solubility Soluble in DMF, DMSO
Appearance Colorless Acicular Crystal
Storage Store at -20°C

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