NG-011
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| Category | Others |
| Catalog number | BBF-03686 |
| CAS | 141731-75-1 |
| Molecular Weight | 662.63 |
| Molecular Formula | C32H38O15 |
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Description
NG-011 is originally isolated from Penicillum verruculosum F-4542 and used as a nerve growth factor (NGF) enhancer.
Specification
| Related CAS | 151271-58-8 |
| Synonyms | NG 011; (7r,12s,16r,24r,28r)-2,4,12,19,21-pentahydroxy-7,16,24,28-tetramethyl-12,13,28,29-tetrahydro-5h,7h,16h,24h-dibenzo[m,w][1,5,10,16,20]pentaoxacyclopentacosine-5,9,14,22,26(8h,11h,17h,25h)-pentone |
| IUPAC Name | (4R,8R,18R,23S,27R)-12,14,23,31,33-pentahydroxy-4,8,18,27-tetramethyl-3,7,17,21,26-pentaoxatricyclo[27.4.0.010,15]tritriaconta-1(29),10(15),11,13,30,32-hexaene-2,6,16,20,25-pentone |
| Canonical SMILES | CC1CC2=C(C(=CC(=C2)O)O)C(=O)OC(CC(=O)OCC(CC(=O)OC(CC3=C(C(=CC(=C3)O)O)C(=O)OC(CC(=O)O1)C)C)O)C |
| InChI | InChI=1S/C32H38O15/c1-15-5-19-9-21(33)11-24(36)29(19)31(41)46-17(3)7-26(38)43-14-23(35)13-28(40)45-16(2)6-20-10-22(34)12-25(37)30(20)32(42)47-18(4)8-27(39)44-15/h9-12,15-18,23,33-37H,5-8,13-14H2,1-4H3/t15-,16-,17-,18-,23+/m1/s1 |
| InChI Key | UQFKAQNXJTZJAU-RZOYPLJHSA-N |
Properties
| Appearance | White Powder |
| Boiling Point | 1079.4°C at 760 mmHg |
| Melting Point | 85-100°C |
| Density | 1.295 g/cm3 |
Reference Reading
1. HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy
Jenna B Honeycutt, William O Thayer, Caroline E Baker, Ruy M Ribeiro, Steven M Lada, Youfang Cao, Rachel A Cleary, Michael G Hudgens, Douglas D Richman, J Victor Garcia Nat Med. 2017 May;23(5):638-643. doi: 10.1038/nm.4319. Epub 2017 Apr 17.
Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is never eradicated. One major barrier to eradication is that the virus infects multiple cell types that may individually contribute to HIV persistence. Tissue macrophages are critical contributors to HIV pathogenesis; however, their specific role in HIV persistence during long-term suppressive ART has not been established. Using humanized myeloid-only mice (MoM), we demonstrate that HIV infection of tissue macrophages is rapidly suppressed by ART, as reflected by a rapid drop in plasma viral load and a dramatic decrease in the levels of cell-associated viral RNA and DNA. No viral rebound was observed in the plasma of 67% of the ART-treated animals at 7 weeks after ART interruption, and no replication-competent virus was rescued from the tissue macrophages obtained from these animals. In contrast, in a subset of animals (~33%), a delayed viral rebound was observed that is consistent with the establishment of persistent infection in tissue macrophages. These observations represent the first direct evidence, to our knowledge, of HIV persistence in tissue macrophages in vivo.
2. NG-011 and NG-012, novel potentiators of nerve growth factor. II. The structure determination of NG-011 and NG-012
M Ito, Y Tsuchida, K Mizoue, K Hanada J Antibiot (Tokyo). 1992 Oct;45(10):1566-72. doi: 10.7164/antibiotics.45.1566.
NG-011 and NG-012, novel potentiators of nerve growth factor (NGF) were isolated from the culture broth of Penicillium verruculosum F-4542. The structures of NG-011 and NG-012 were elucidated by their spectral analysis and degradation experiments as shown in Fig. 1.
3. Antifungal macrocyclic polylactones from Penicillium verruculosum
J Breinholt, G W Jensen, R I Nielsen, C E Olsen, J C Frisvad J Antibiot (Tokyo). 1993 Jul;46(7):1101-8. doi: 10.7164/antibiotics.46.1101.
Three macrocyclic polylactones have been isolated from Penicillium verruculosum. Two were found to be novel and the third to be identical with NG-012(1). Their structures were elucidated by spectroscopic and chemical methods. A full assignment of 1H- and 13C-resonances in acetone-d6 are given for all three compounds. The compounds show antifungal activity.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
