Nidulal
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| Category | Antibiotics |
| Catalog number | BBF-02603 |
| CAS | 185853-14-9 |
| Molecular Weight | 276.28 |
| Molecular Formula | C15H16O5 |
| Purity | 95% |
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Description
Nidulal is originally isolated from Nidula candida 87220. Nidulal induces differentiation of human promyelocytic leukemia cells. In COS-7 cells it selectively activates AP-1 dependent signal transduction in a manner which is similar to TPA/PMA.
Specification
| Synonyms | 4-(8-Methyl-4,7-dioxo-1,6-dioxaspiro[4.4]nona-2,8-dien-3-yl)cyclohexanecarbaldehyde |
| Storage | Store at -20°C |
| IUPAC Name | 4-(3-methyl-2,9-dioxo-1,6-dioxaspiro[4.4]nona-3,7-dien-8-yl)cyclohexane-1-carbaldehyde |
| Canonical SMILES | CC1=CC2(C(=O)C(=CO2)C3CCC(CC3)C=O)OC1=O |
| InChI | InChI=1S/C15H16O5/c1-9-6-15(20-14(9)18)13(17)12(8-19-15)11-4-2-10(7-16)3-5-11/h6-8,10-11H,2-5H2,1H3 |
| InChI Key | NQSKLGFKNUGTFE-UHFFFAOYSA-N |
Properties
| Appearance | Colorless Oily Matter |
| Antibiotic Activity Spectrum | neoplastics (Tumor) |
| Boiling Point | 512.4±50.0°C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Soluble in ethanol, methanol or DMSO. |
Reference Reading
1. Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida
G Erkel, U Becker, T Anke, O Sterner J Antibiot (Tokyo). 1996 Dec;49(12):1189-95. doi: 10.7164/antibiotics.49.1189.
Nidulal (1), a novel inducer of differentiation of human HL-60 promyelocytic leukemia cells, was isolated from fermentations of the basidiomycete Nidula candida together with low amounts of niduloic acid (2). Both compounds are bisabolane sesquiterpenes. Their structures were elucidated by spectroscopic methods. In reporter gene assays nidulal (1) preferentially activated the transcription factor complex AP-1-mediated expression of secreted alkaline phosphatase in COS-7 cells. In addition nidulal (1) and niduloic acid (2) exhibited weak cytotoxic and antibiotic activities.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
