NK10958P
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| Category | Bioactive by-products |
| Catalog number | BBF-03295 |
| CAS | |
| Molecular Weight | 310.4 |
| Molecular Formula | C18H30O4 |
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Description
NK10958P is a plant growth regulator produced by Streptomyces sp. NK10958.
Specification
| Synonyms | NK-10958P |
| IUPAC Name | (2R,3R)-2-[(E,2R,3S,4R,5S)-2,4-dihydroxy-3,5-dimethylnon-7-enyl]-3-ethyl-2,3-dihydropyran-6-one |
| Canonical SMILES | CCC1C=CC(=O)OC1CC(C(C)C(C(C)CC=CC)O)O |
| InChI | InChI=1S/C18H30O4/c1-5-7-8-12(3)18(21)13(4)15(19)11-16-14(6-2)9-10-17(20)22-16/h5,7,9-10,12-16,18-19,21H,6,8,11H2,1-4H3/b7-5+/t12-,13-,14+,15+,16+,18+/m0/s1 |
| InChI Key | DGTXWIIFBBXJAA-BZQBGSLUSA-N |
Properties
| Appearance | Needle Crystal |
| Melting Point | 77-78°C |
Reference Reading
1. Cell cycle arrest and antitumor activity of pironetin and its derivatives
M Kondoh, T Usui, S Kobayashi, K Tsuchiya, K Nishikawa, T Nishikiori, T Mayumi, H Osada Cancer Lett. 1998 Apr 10;126(1):29-32. doi: 10.1016/s0304-3835(97)00528-4.
The biological effects of pironetin and its derivatives on cell cycle progression and antitumor activity were studied. At 10-20 ng/ml, both pironetin and its demethyl derivative, NK10958P completely inhibited the cell proliferation of 3Y1 cells, however, epoxypironetin showed only a weak inhibitory activity. The cell cycle analysis revealed that these compounds arrested the cell cycle progression at the M-phase in a dose-dependent manner. These antiproliferative effects of pironetin were also observed in the range 5-25 ng/ml with several tumor cell lines. In CDF1-SLC mice bearing P388 leukemia cells, the intraperitoneal administration of 6.3 mg/kg pironetin over a 5-day period showed a moderate antitumor effect (T/C, 128%). As the chemical structure of pironetin is different from other M-phase inhibitors such as colchicine or vinblastine, pironetin will be the lead compound for a potential new antitumor drug.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
