Norfloxacin

This study reports the efficiency of gamma-ray irradiation to degrade quinolone antibiotic, norfloxacin, in aqueous solution. Laboratory batch experiments were conducted to determine the "pseudo-first" order degradation kinetics of norfloxacin in the concentration ranges of 3.4-16.1 mg L-1 by gamma-ray irradiation. The dose constant was found to be dependent on the initial concentration of norfloxacin and gamma-ray irradiation dose rate (D r). The saturation of norfloxacin sample solutions with N2, air or N2O, and the presence of tert-butanol and 2-propanol showed that •OH played more crucial role in the degradation of norfloxacin. The second order rate constants of •OH, eaq -, and •H with norfloxacin were calculated to be 8.81 × 109, 9.54 × 108, and 1.10 × 109 M-1 s-1, respectively. The effects of various additives including CO3 2-, HCO3 -, NO3 -, NO2 -, and thiourea and the pH of the medium on the degradation of norfloxacin were also investigated.

BACKGROUND: Tannins have shown inhibitory effects against pathogenic bacteria, and these properties make tannins potential modifying agents in bacterial resistance.