OA-6129 B1
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| Category | Antibiotics |
| Catalog number | BBF-03307 |
| CAS | |
| Molecular Weight | 473.5 |
| Molecular Formula | C20H31N3O8S |
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Description
OA-6129 B1 is a carbapenem antibiotic produced by Streptomyces sp. OA-6129. It inhibits gram-positive, gram-negative bacteria and beta-lactamase.
Specification
| Synonyms | Antibiotic OA 6129B1; OA 6129B1; OA-6129B1 |
| IUPAC Name | (5R,6R)-3-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-6-[(1S)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| Canonical SMILES | CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCNC(=O)CCNC(=O)C(C(C)(C)CO)O)O |
| InChI | InChI=1S/C20H31N3O8S/c1-10(25)14-11-8-12(15(19(30)31)23(11)18(14)29)32-7-6-21-13(26)4-5-22-17(28)16(27)20(2,3)9-24/h10-11,14,16,24-25,27H,4-9H2,1-3H3,(H,21,26)(H,22,28)(H,30,31)/t10-,11+,14-,16-/m0/s1 |
| InChI Key | HNLNYXRYILRJHY-VAECKANCSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
Reference Reading
1. Structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics produced by Streptomyces sp. OA-6129
T Yoshioka, I Kojima, K Isshiki, A Watanabe, Y Shimauchi, M Okabe, Y Fukagawa, T Ishikura J Antibiot (Tokyo). 1983 Nov;36(11):1473-82. doi: 10.7164/antibiotics.36.1473.
The chemical structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics having a pantetheinyl group at C-3 were elucidated by spectroscopic analysis and chemical transformation as presented in Fig. 1.
2. Mutagenesis of OA-6129 carbapenem-producing blocked mutants and the biosynthesis of carbapenems
I Kojima, Y Fukagawa, M Okabe, T Ishikura, N Shibamoto J Antibiot (Tokyo). 1988 Jul;41(7):899-907. doi: 10.7164/antibiotics.41.899.
Streptomyces fulvoviridis A933 17M9 1501 is an A933 acylase-defective mutant derived from S. fulvoviridis A933 17M9 and thus produces the OA-6129 group of carbapenems and carbapenams. By further mutation of mutant 1501, 4 types of mutants (OA-6129 A + B1 + B2 producers; OA-6129 A + B2 producers; an OA-6129 A producer; non-producers) were obtained. The second type of mutant strains 4N 3607, 5NA 3949-40 and 5NE 252 proved useful for the fermentative production of carbapenem OA-6129 B2. These results of mutagenesis demonstrated that the sequence of carbapenem bioconversion in the horizontal route was hydroxylation at C-8----isomerization at C-6----sulfation at C-8 hydroxyl.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
