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Obscurolide A1

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Obscurolide A1
Category Enzyme inhibitors
Catalog number BBF-04126
CAS 144397-99-9
Molecular Weight 291.30
Molecular Formula C15H17NO5
Purity ≥98%

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

Obscurolide A1 is a weak phosphodiesterase inhibitor isolated from Streptomyces viridochromogenes.

  • Specification
  • Properties
  • Reference Reading
  • Price Product List
Synonyms 4-[[2-[(E)-3-hydroxybut-1-enyl]-5-oxooxolan-3-yl]amino]benzoic acid
Storage Store at -20°C
IUPAC Name 4-[[2-[(E)-3-hydroxybut-1-enyl]-5-oxooxolan-3-yl]amino]benzoic acid
Canonical SMILES CC(C=CC1C(CC(=O)O1)NC2=CC=C(C=C2)C(=O)O)O
InChI InChI=1S/C15H17NO5/c1-9(17)2-7-13-12(8-14(18)21-13)16-11-5-3-10(4-6-11)15(19)20/h2-7,9,12-13,16-17H,8H2,1H3,(H,19,20)/b7-2+
InChI Key IZSWILLJDXDGDJ-FARCUNLSSA-N
Appearance Off-white to Pale Yellow Powder
Boiling Point 575.6°C at 760 mmHg
Density 1.427 g/cm3
1. Metabolic products of microorganisms. 261. Obscurolides, a novel class of phosphodiesterase inhibitors from streptomyces. I. Production, isolation, structural elucidation and biological activity of obscurolides A1 to A4
W Keller-Schierlein, H Hoff, M Ritzau, H Zähner, A Zeeck, H Drautz, J E Schultz, S Philipps, H P Fiedler J Antibiot (Tokyo) . 1992 Jul;45(7):1096-107. doi: 10.7164/antibiotics.45.1096.
A novel class of butyrolactones, named obscurolides, was isolated from the culture filtrate of Streptomyces viridochromogenes by chemical screening methods. The structural elucidation of the obscurolides A1 to A4 (1 approximately 4) is described. The carboxy group of the 4-aminobenzoic acid moiety of obscurolide A1 (1) is reduced in the other compounds. The isolated natural products have been proved to be diastereomeric mixtures by a partial racemization at C-7 which belongs to an allylic alcohol system. The obscurolides showed a weak inhibitory activity against calcium/calmodulin-dependent and independent phosphodiesterases from bovine.

Bio Calculators

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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