Ofloxacin
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| Category | Antibiotics |
| Catalog number | BBF-04536 |
| CAS | 82419-36-1 |
| Molecular Weight | 361.37 |
| Molecular Formula | C18H20FN3O4 |
| Purity | >98% |
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Description
Ofloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic. It has antimicrobial activity. It can inhibit DNA gyrase, Topo II (topoisomerase II) and Topo IV (Topo II α).
Specification
| Related CAS | 118120-51-7 (hydrochloride) |
| Synonyms | RS-10085; RS 10085; RS10085; DL-8280; DR-3355; ORF-28489; Ru-43280; 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid; Ofloxacine; HOE-280; Exocin; Flobacin; Floxil; Floxin; Monoflocet; Ocuflox |
| Storage | Store at 2-8°C |
| IUPAC Name | 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid |
| Canonical SMILES | CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O |
| InChI | InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25) |
| InChI Key | GSDSWSVVBLHKDQ-UHFFFAOYSA-N |
| Source | Synthetic |
Properties
| Appearance | White Crystalline Powder |
| Application | Anti-bacterial agents; anti-infective agents, Urinary; nucleic acid synthesis inhibitors |
| Boiling Point | 571.5±50.0°C (Predicted) |
| Melting Point | >240°C (dec.) |
| Flash Point | 299.4±30.1 °C |
| Density | 1.48 g/cm3 |
| Solubility | Slightly soluble in DMSO, Methanol (Heated) |
Reference Reading
1.Antibiotic resistance and polymorphism in the quinolone resistance-determining region of Campylobacter spp. isolated from 1-day-old ducklings.
Hamed EA1, AbdelRahman MA2, Shalaby AG2, Morsy MM2, Nasef SA2. Vet J. 2016 May;211:100-3. doi: 10.1016/j.tvjl.2015.09.020. Epub 2015 Sep 28.
Thirty-three isolates of Campylobacter coli and three isolates of Campylobacter jejuni were recovered from 150 1-day-old ducklings. All isolates were sensitive to chloramphenicol and amikacin, but resistant to sulfamethoxazole-trimethoprim (SXT) by the disc diffusion method. Most isolates were susceptible to tetracycline and erythromycin, but resistant to ofloxacin and ciprofloxacin. Of the 33 C. coli isolates, nine were positive for the tetracycline resistance gene tet(O), although only two of these were resistant to tetracycline in the disc diffusion test. None of the isolates possessed mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene infrequently linked to FQ-resistance. The finding indicated that ducklings may be a source of antibiotic resistant Campylobacter spp. with potential poultry and public health hazard.
2.Predictors of cure in rifampicin-resistant tuberculosis in prison settings with low loss to follow-up.
Gurbanova E1, Mehdiyev R2, Blondal K3, Altraja A4. Int J Tuberc Lung Dis. 2016 May;20(5):645-51. doi: 10.5588/ijtld.15.0545.
OBJECTIVE: To determine the factors predictive of cure among inmates with pulmonary rifampicin-resistant tuberculosis (R(R)-TB).
3.Drug resistant strains of Mycobacterium tuberculosis identified through PCR-RFLP from patients of Central Punjab, Pakistan.
Riaz M1, Mahmood Z2, Javed MT3, Javed I1, Shahid M1, Abbas M4, Ehtisham-Ul-Haque S5. Int J Immunopathol Pharmacol. 2016 Apr 11. pii: 0394632016638100. [Epub ahead of print]
The study was carried out to determine, by PCR-RFLP, the magnitude of drug resistance inMycobacterium tuberculosis The study was carried out on 221 random sputum samples collected from patients and 120 suspected cases of drug resistance. Genetic variation in drug-resistant strains was evaluated through PCR-RFLP for isoniazid, ethambutol, streptomycin, and ofloxacin. Out of 341 patients, 91.5% were confirmed asM. tuberculosiscomplex infected on the basis of PCR. The random samples revealed resistance in 8.2% cases, while 73.3% of those with suspected drug resistance were found resistant. Among drug-resistant isolates, 56.1% were resistant to a single drug, 33.3% to two drugs, and 10.6% to more than two drugs. Ofloxacin resistance was observed along with isoniazid, ethambutol, and streptomycin in 6.5% cases. Resistance to isoniazid was observed in 61% cases, to ethambutol in 50.4%, and to streptomycin in 43.1% cases. It was concluded that PCR-RFLP is a useful molecular technique for the rapid detection of mutations in drug-resistant tuberculosis patients and may be used to diagnose drug resistance at the earliest.
4.Adsorption mechanism of different organic chemicals on fluorinated carbon nanotubes.
Li H1, Zheng N1, Liang N1, Zhang D1, Wu M1, Pan B2. Chemosphere. 2016 Apr 5;154:258-265. doi: 10.1016/j.chemosphere.2016.03.099. [Epub ahead of print]
Multi-walled carbon nanotubes (MC) were fluorinated by a solid-phase reaction method using polytetrafluoroethylene (PTFE). The surface alteration of carbon nanotubes after fluorination (MC-F) was confirmed based on surface elemental analysis, TEM and SEM. The incorporation of F on MC surface was discussed as F incorporation on carbon defects, replacement of carboxyl groups, as well as surface coating of PTFE. The adsorption performance and mechanisms of MC-F for five kinds of representative organic compounds: sulfamethoxazole (SMX), ofloxacin (OFL), norfloxacin (NOR), bisphenol a (BPA) and phenanthrene (PHE) were investigated. Although BET-N2 surface area of the investigated CNTs decreased after fluorination, the adsorption of all five chemicals increased. Because of the glassification of MC-F surface coating during BET-N2 surface area measurement, the accessible surface area of MC-F was underestimated. Desorption hysteresis was generally observed in all the sorption systems in this study, and the desorption hysteresis of MC-F were stronger than the pristine CNTs.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
