Oxacillin Sodium Salt Monohydrate
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| Category | Antibiotics |
| Catalog number | BBF-04557 |
| CAS | 7240-38-2 |
| Molecular Weight | 441.43 |
| Molecular Formula | C19H18N3NaO5S.H2O |
| Purity | 96% |
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Description
Oxacillin sodium monohydrate is a semi-synthetic antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.
Specification
| Related CAS | 66-79-5 (free acid) |
| Synonyms | (2S,5R,6R)-3,3-Dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt Hydrate; Penicillin P-12 Hydrate; Sodium Oxacillin Hydrate; BRL-1400 Hydrate; Bactocill Hydrate; Bristopen Hydrate; Stapenor Hydrate; Oxacillin sodium hydrate; Cryptocillin; Prostaphlin; Stapenor; BAY-M-1099; BAY M 1099 |
| Storage | Store at -20°C |
| IUPAC Name | sodium;(2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate |
| Canonical SMILES | CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+] |
| InChI | InChI=1S/C19H19N3O5S.Na.H2O/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1./s1 |
| InChI Key | ZVIYWUUZWWBNMB-VICXVTCVSA-M |
Properties
| Appearance | White to Off-white Solid |
| Antibiotic Activity Spectrum | Bacteria |
| Boiling Point | 686.8°C at 760 mmHg |
| Melting Point | >169°C (dec.) |
| Solubility | Soluble in Methanol (Slightly), Water (Slightly) |
Reference Reading
1.Tissue distribution of oxacillin and ampicillin in the isolated perfused bovine udder.
Ehinger AM1, Kietzmann M. J Vet Med A Physiol Pathol Clin Med. 2000 Apr;47(3):157-68.
In vivo, tissue distribution of intra-mammarily administered antibiotics is mostly only assessed by sampling milk and blood. Therefore, the described study analysed whether measurement of tissue concentrations makes sense in vitro instead. Isolated bovine udders were perfused with gassed and warmed Tyrode solution. To four front and rear quarters each, 1000 mg oxacillin in 7.5 ml vehicle was administered intracisternally, completely formulated as sodium monohydrate in two lactation ointments (with or without sodium dodecylsulphate) or 80% as benzathine salt in a dry-off ointment. Over 3 h, perfusate and glandular tissue from different locations were sampled and analysed by high pressure liquid chromatography. With increasing vertical distance to the teat base, the tissue concentration of antibiotics decreased. With the lactation ointment containing sodium dodecylsulphate, lower oxacillin concentrations were reached in glandular tissue and lymph nodes compared to those without.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
