PA-46101 A
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| Category | Antibiotics |
| Catalog number | BBF-03327 |
| CAS | 130743-11-2 |
| Molecular Weight | 983.1 |
| Molecular Formula | C52H70O18 |
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Description
PA-46101 A is a macrolide antibiotic isolated from the culture broth of Streptomyces sp. PA-46101. It is active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also against a limited number of aerobic Gram-positive bacteria.
Specification
| Synonyms | PA 46101 A |
| IUPAC Name | (1S,3R,6R,11S,14S,15R,16S,19R,20S)-3-ethyl-16,26-dihydroxy-15-[(2S,3R,4S,5R,6R)-3-hydroxy-4-[(2S,4S,5S,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-5-(2-methoxy-6-methylbenzoyl)oxy-6-methyloxan-2-yl]oxy-6,12,20-trimethyl-21,24-dioxo-22,25-dioxapentacyclo[21.2.1.01,6.011,20.014,19]hexacosa-4,12,23(26)-triene-4-carboxylic acid |
| Canonical SMILES | CCC1CC23C(=C(C(=O)O2)OC(=O)C4(C5CCC(C(C5C=C(C4CCCCC3(C=C1C(=O)O)C)C)OC6C(C(C(C(O6)C)OC(=O)C7=C(C=CC=C7OC)C)OC8CC(C(C(O8)C)OC)O)O)O)C)O |
| InChI | InChI=1S/C52H70O18/c1-10-28-22-52-44(56)43(47(60)70-52)69-49(61)51(7)31(15-11-12-19-50(52,6)23-30(28)45(57)58)25(3)20-29-32(51)17-18-33(53)41(29)68-48-38(55)42(66-36-21-34(54)39(63-9)26(4)64-36)40(27(5)65-48)67-46(59)37-24(2)14-13-16-35(37)62-8/h13-14,16,20,23,26-29,31-34,36,38-42,48,53-56H,10-12,15,17-19,21-22H2,1-9H3,(H,57,58)/t26-,27-,28-,29+,31+,32-,33+,34+,36+,38-,39-,40-,41-,42+,48+,50-,51-,52-/m1/s1 |
| InChI Key | GUUBJNZJQYYEGQ-FODYDRHCSA-N |
Properties
| Antibiotic Activity Spectrum | Gram-positive bacteria; Gram-negative bacteria |
Reference Reading
1. Isolation, characterization and structures of PA-46101 A and B
M Matsumoto, Y Kawamura, Y Yoshimura, Y Terui, H Nakai, T Yoshida, J Shoji J Antibiot (Tokyo). 1990 Jul;43(7):739-47. doi: 10.7164/antibiotics.43.739.
New antibiotics, PA-46101 A and B, were isolated from the culture broth of a Streptomycete. The molecular formulae of A and B were determined to be C52H70O18 and C61H86O22, respectively, by elemental analyses, NMR and mass spectrometry. Their structures were elucidated by X-ray crystallography and NMR spectroscopy. These antibiotics are active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also against a limited number of aerobic Gram-positive bacteria.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
