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Palmitoylcoprogen

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Palmitoylcoprogen
Category Others
Catalog number BBF-05009
CAS 1807362-49-7
Molecular Weight 1018.06
Molecular Formula C49H81FeN6O13

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

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Synonyms Iron, [(3E)-5-[(hydroxy-κO)[3-[(2S,5S)-5-[3-[(hydroxy-κO)[(2E)-5-hydroxy-3-methyl-1-(oxo-κO)-2-penten-1-yl]amino]propyl]-3,6-dioxo-2-piperazinyl]propyl]amino]-3-methyl-5-(oxo-κO)-3-penten-1-yl N5-(hydroxy-κO)-N5-[(2E)-5-hydroxy-3-methyl-1-(oxo-κO)-2-penten-1-yl]-N2-(1-oxohexadecyl)-L-ornithinato(3-)]-
1. Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021
Takahito Ouchi, Yoshihiro Watanabe, Kenichi Nonaka, Reiko Muramatsu, Chikako Noguchi, Miho Tozawa, Rei Hokari, Aki Ishiyama, Rima Koike, Hidehito Matsui, Yukihiro Asami, Yuki Inahashi, Takahiro Ishii, Toshiaki Teruya, Masato Iwatsuki, Hideaki Hanaki, Satoshi Ōmura J Antibiot (Tokyo). 2020 Jun;73(6):365-371. doi: 10.1038/s41429-020-0292-7. Epub 2020 Mar 6.
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.

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It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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