Palmitoylcoprogen

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Palmitoylcoprogen
Category Others
Catalog number BBF-05009
CAS 1807362-49-7
Molecular Weight 1018.06
Molecular Formula C49H81FeN6O13

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Specification

Synonyms Iron, [(3E)-5-[(hydroxy-κO)[3-[(2S,5S)-5-[3-[(hydroxy-κO)[(2E)-5-hydroxy-3-methyl-1-(oxo-κO)-2-penten-1-yl]amino]propyl]-3,6-dioxo-2-piperazinyl]propyl]amino]-3-methyl-5-(oxo-κO)-3-penten-1-yl N5-(hydroxy-κO)-N5-[(2E)-5-hydroxy-3-methyl-1-(oxo-κO)-2-penten-1-yl]-N2-(1-oxohexadecyl)-L-ornithinato(3-)]-

Reference Reading

1. Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021
Takahito Ouchi, Yoshihiro Watanabe, Kenichi Nonaka, Reiko Muramatsu, Chikako Noguchi, Miho Tozawa, Rei Hokari, Aki Ishiyama, Rima Koike, Hidehito Matsui, Yukihiro Asami, Yuki Inahashi, Takahiro Ishii, Toshiaki Teruya, Masato Iwatsuki, Hideaki Hanaki, Satoshi Ōmura J Antibiot (Tokyo). 2020 Jun;73(6):365-371. doi: 10.1038/s41429-020-0292-7. Epub 2020 Mar 6.
Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.

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