Panclicin A

Name: Panclicin A
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Enzyme inhibitors
Catalog number	BBF-02349
CAS	160669-37-4
Molecular Weight	453.65
Molecular Formula	C26H47NO5

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

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Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Str. sp. NR 0619. It's an enzyme inhibitor.

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Synonyms	L-Alanine, N-formyl-, (1S)-1-[[(2S,3S)-3-(8-methylnonyl)-4-oxo-2-oxetanyl]methyl]octyl ester; L-Alanine, N-formyl-, 1-[[3-(8-methylnonyl)-4-oxo-2-oxetanyl]methyl]octyl ester, [2S-[2a[R(R)],3b]]-; (-)-Panclicin A
IUPAC Name	[(2S)-1-[(2S,3S)-3-(8-methylnonyl)-4-oxooxetan-2-yl]nonan-2-yl] (2S)-2-formamidopropanoate
Canonical SMILES	CCCCCCCC(CC1C(C(=O)O1)CCCCCCCC(C)C)OC(=O)C(C)NC=O
InChI	InChI=1S/C26H47NO5/c1-5-6-7-9-13-16-22(31-25(29)21(4)27-19-28)18-24-23(26(30)32-24)17-14-11-8-10-12-15-20(2)3/h19-24H,5-18H2,1-4H3,(H,27,28)/t21-,22-,23-,24-/m0/s1
InChI Key	LRDWQJMXGXVRRG-ZJZGAYNASA-N

Appearance	Colorless Powder
Solubility	Soluble in Chloroform

1. Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation

K Yoshinari, M Aoki, T Ohtsuka, N Nakayama, Y Itezono, M Mutoh, J Watanabe, K Yokose J Antibiot (Tokyo). 1994 Dec;47(12):1376-84. doi: 10.7164/antibiotics.47.1376.

Panclicins A-E are novel and potent pancreatic lipase inhibitors produced by Streptomyces sp. NR 0619. Their structures have been elucidated based on NMR and FAB-MS experiments. The relative configurations have also been determined by NMR experiments. The absolute stereochemistry has been determined by the chiral HPLC analysis of the hydrolysates of panclicins A and B and by modified Mosher's method on a derivative of panclicin A. They are structurally related to beta-lactone esterase inhibitors of microbial origin, lipstatin, valilactone, ebelactones and esterastin. Panclicins also contain a beta-lactone structure with two alkyl chains, one of which has an N-formylalanyloxy or N-formylglycyloxy substituent.

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Panclicin A

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