Panclicin A
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
| Category | Enzyme inhibitors |
| Catalog number | BBF-02349 |
| CAS | 160669-37-4 |
| Molecular Weight | 453.65 |
| Molecular Formula | C26H47NO5 |
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Description
It is produced by the strain of Str. sp. NR 0619. It's an enzyme inhibitor.
Specification
| Synonyms | L-Alanine, N-formyl-, (1S)-1-[[(2S,3S)-3-(8-methylnonyl)-4-oxo-2-oxetanyl]methyl]octyl ester; L-Alanine, N-formyl-, 1-[[3-(8-methylnonyl)-4-oxo-2-oxetanyl]methyl]octyl ester, [2S-[2a[R*(R*)],3b]]-; (-)-Panclicin A |
| IUPAC Name | [(2S)-1-[(2S,3S)-3-(8-methylnonyl)-4-oxooxetan-2-yl]nonan-2-yl] (2S)-2-formamidopropanoate |
| Canonical SMILES | CCCCCCCC(CC1C(C(=O)O1)CCCCCCCC(C)C)OC(=O)C(C)NC=O |
| InChI | InChI=1S/C26H47NO5/c1-5-6-7-9-13-16-22(31-25(29)21(4)27-19-28)18-24-23(26(30)32-24)17-14-11-8-10-12-15-20(2)3/h19-24H,5-18H2,1-4H3,(H,27,28)/t21-,22-,23-,24-/m0/s1 |
| InChI Key | LRDWQJMXGXVRRG-ZJZGAYNASA-N |
Properties
| Appearance | Colorless Powder |
| Solubility | Soluble in Chloroform |
Reference Reading
1. Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation
K Yoshinari, M Aoki, T Ohtsuka, N Nakayama, Y Itezono, M Mutoh, J Watanabe, K Yokose J Antibiot (Tokyo). 1994 Dec;47(12):1376-84. doi: 10.7164/antibiotics.47.1376.
Panclicins A-E are novel and potent pancreatic lipase inhibitors produced by Streptomyces sp. NR 0619. Their structures have been elucidated based on NMR and FAB-MS experiments. The relative configurations have also been determined by NMR experiments. The absolute stereochemistry has been determined by the chiral HPLC analysis of the hydrolysates of panclicins A and B and by modified Mosher's method on a derivative of panclicin A. They are structurally related to beta-lactone esterase inhibitors of microbial origin, lipstatin, valilactone, ebelactones and esterastin. Panclicins also contain a beta-lactone structure with two alkyl chains, one of which has an N-formylalanyloxy or N-formylglycyloxy substituent.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
