Paromomycin sulfate
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| Category | Antibiotics |
| Catalog number | BBF-03812 |
| CAS | 1263-89-4 |
| Molecular Weight | 615.63 (free base) |
| Molecular Formula | C23H45N5O14.xH2O4S |
| Purity | >98% |
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Description
Paromomycin sulfate is an aminoglycoside antimicrobial agent derived from Streptomyces sp. AG-P 1441.
Specification
| Related CAS | 7542-37-2 (free base) |
| Synonyms | D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:x); 1600 Antibiotic; Aminosidin sulfate; Aminosidine sulfate; Aminoxidin; Farmiglucin; Farminosidin; FI 5853; Gabbroral; Humagel; Humatin; Humycin sulfate; Paramicina; Pargonyl; Paricina; Sinosid |
| Storage | Store at 2-8°C |
| IUPAC Name | (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid |
| Canonical SMILES | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O |
| InChI | InChI=1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 |
| InChI Key | LJRDOKAZOAKLDU-UDXJMMFXSA-N |
Properties
| Appearance | White to Light Yellow Solid |
| Boiling Point | 939.8°C at 760 mmHg |
| Melting Point | >200°C |
| Solubility | Soluble in Water |
Reference Reading
1. Robust polymeric nanoparticles for the delivery of aminoglycoside antibiotics using carboxymethyldextran-b-poly(ethyleneglycols) lightly grafted with n-dodecyl groups
Ghareb M. Soliman, Janek Szychowski, Stephen Hanessian* and Francoise M. Winnik*. Soft Matter, 2010, 6, 4504–4514
Solutions for analysis were filtered through a 0.45 μm Millex Millipore PVDF membrane prior to measurement. Isothermal titration calorimetry (ITC)measurementswere carried out with a Microcal VP-ITC instrument. Solutions of neomycin sulfate, paromomycin sulfate and CMD-PEG were prepared in a phosphate buffer (10 mM, pH 7.0). Prior to measurements all solutions were degassed under vacuum for about 10 min to eliminate any air bubbles. Aliquots of the neomycin sulfate solution (10 μL, 6.0 g/L, 6.6mM, 39.6mM amine) or paromomycin sulfate solution (10μL, 5.65 g/L, 7.92mM, 39.6m Mamine) were injected from a 300 mL continuously stirred (300-rpm) syringe into a solution of CMD-PEG (1.43 mL, 0.75 g/L, 2.61 mM carboxylate) at 25 ℃. Heats of dilution and mixing were determined in control experiments by injecting aliquots (10μL) of each drug solution into the same buffer (1.43mL).Atotal of 28 aliquotswere injected into the sample cell in intervals of 300 s. The calorimetric datawere analyzed and converted to enthalpy change using Microcal ORIGIN 7.0.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
