Parvisporin

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Category Others
Catalog number BBF-02956
CAS
Molecular Weight 390.51
Molecular Formula C23H34O5

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Description

It is a neuritogenic agent produced by the strain of Stachyborrys parvispora F4708. It promotes the enlargement of the neural sinus of P12 cells, and the effect of Stachybotrin C is obvious, but the effect of Parvisporin is weak.

Specification

IUPAC Name 2,4-dihydroxy-6-(hydroxymethyl)-3-[(2E,6E)-11-hydroxy-3,7,11-trimethyldodeca-2,6-dienyl]benzaldehyde
Canonical SMILES CC(=CCCC(=CCC1=C(C=C(C(=C1O)C=O)CO)O)C)CCCC(C)(C)O
InChI InChI=1S/C23H34O5/c1-16(9-6-12-23(3,4)28)7-5-8-17(2)10-11-19-21(26)13-18(14-24)20(15-25)22(19)27/h7,10,13,15,24,26-28H,5-6,8-9,11-12,14H2,1-4H3/b16-7+,17-10+
InChI Key IOIZASRPFAFSMJ-CHGLLVKUSA-N

Properties

Appearance Pale Yellow to White Powder
Melting Point 73-75°C
Solubility Soluble in Methanol

Reference Reading

1. Stachybotrin C and parvisporin, novel neuritogenic compounds. I. Taxonomy, isolation, physico-chemical and biological properties
Y Nozawa, K Yamamoto, M Ito, N Sakai, K Mizoue, F Mizobe, K Hanada J Antibiot (Tokyo). 1997 Aug;50(8):635-40. doi: 10.7164/antibiotics.50.635.
Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary culture of cerebral cortical neurons. Parvisporin demonstrated only weak neuritogenic activity.
2. Stachybotrin C and parvisporin, novel neuritogenic compounds. II. Structure determination
Y Nozawa, M Ito, K Sugawara, K Hanada, K Mizoue J Antibiot (Tokyo). 1997 Aug;50(8):641-5. doi: 10.7164/antibiotics.50.641.
The structures of stachybotrin C and parvisporin have been determined by spectroscopic analyses and chemical derivatization. Stachybotrin C contains a unique pyrano-isoindolinone ring system, while parvisporin has a hydroxyl farnesyl phenol structure.

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