Parvodicin complex

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Parvodicin complex
Category Antibiotics
Catalog number BBF-02667
CAS 187888-13-7
Molecular Weight 1732.53
Molecular Formula C83H88Cl2N8O29 (for C1)
Purity >95% by HPLC

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Description

It is produced by the strain of Actinomadura paroosalo. It's a glycopeptide antibiotic. It has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and enterococcus faecalis. Parvodicin C1 and C2 have stronger antibacterial effects than Parvodicin C3 and C4. The antibacterial activity of Parvodicin C is 1-4 times stronger than Tecomycin and 2-4 times stronger than vancomycin. The terminal branching activity of lipid chains is greater than straight chains (C1>C2>C3>C4, B1>B2), and the chain length is greater than short chains (C2>B). The half-life of Parvodicin C1 is longer in vivo than vancomycin and Archeomycin.

Specification

Synonyms A 40926 complex
Storage Store at -20°C
Source Actinomadura parvosata

Properties

Appearance Fawn to light tan solid
Antibiotic Activity Spectrum Gram-positive bacteria
Solubility Soluble in Ethanol, Methanol, DMF, DMSO, Water

Reference Reading

1. Parvodicin, a novel glycopeptide from a new species, Actinomadura parvosata: discovery, taxonomy, activity and structure elucidation
M DiPaolo, S L Heald, H S Allaudeen, A J Giovenella, S A Carr, S K Chung, M R Burke, P DePhillips, J J Dingerdissen, S B Christensen J Antibiot (Tokyo) . 1987 Jul;40(7):970-90. doi: 10.7164/antibiotics.40.970.
An extensive taxonomic investigation identified strain SK&F-AAJ-271 as a new species, designated Actinomadura parvosata. Fermentations of this organism produce a complex of acidic, lipophilic glycopeptide antibiotics, the parvodicins. Structures for seven of the isolated components were derived from a combination of mass spectral, high-field NMR and chemical techniques. The O-acetyl functionality present in two of the isolated components is a structural feature unique among the known members of this class of antibiotics. The parvodicins are active in vitro against a range of Gram-positive bacteria. The most active parvodicin, C1, produces high serum levels in vivo and has the potential for a long duration of action.

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