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PB-5266 A

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PB-5266 A
Category Antibiotics
Catalog number BBF-03330
CAS 108065-94-7
Molecular Weight 437.39
Molecular Formula C13H19N5O10S

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

PB-5266 A is a monobactam antibiotic isolated from the culture filtrate of Cytophaga johnsonae PB-5266. It exhibited weak antibacterial activity against a sensitive mutant of Escherichia coli to beta-lactam antibiotics.

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Synonyms Antibiotic PB-5266A
IUPAC Name (3R)-3-[[(E)-4-amino-2-[[(2R)-2-[[(2S)-2,3-dihydroxypropanoyl]amino]propanoyl]amino]-4-oxobut-2-enoyl]amino]-2-oxoazetidine-1-sulfonic acid
Canonical SMILES CC(C(=O)NC(=CC(=O)N)C(=O)NC1CN(C1=O)S(=O)(=O)O)NC(=O)C(CO)O
InChI InChI=1S/C13H19N5O10S/c1-5(15-12(24)8(20)4-19)10(22)16-6(2-9(14)21)11(23)17-7-3-18(13(7)25)29(26,27)28/h2,5,7-8,19-20H,3-4H2,1H3,(H2,14,21)(H,15,24)(H,16,22)(H,17,23)(H,26,27,28)/b6-2+/t5-,7-,8+/m1/s1
InChI Key TXLOYBYUSQMOIL-RZSWNVQPSA-N
1. PB-5266 A, B and C, new monobactams. II. Physico-chemical properties and chemical structures
T Kato, H Hinoo, Y Terui, J Nishikawa, Y Nakagawa, Y Ikenishi, J Shoji J Antibiot (Tokyo). 1987 Feb;40(2):139-44. doi: 10.7164/antibiotics.40.139.
The chemical structures of three new monobactams, PB-5266 A, B and C, were elucidated by their physico-chemical properties and spectrometric studies. In contrast to previously described monobactams, they all possess a dehydroasparagine residue.
2. PB-5266 A, B and C, new monobactams. I. Taxonomy, fermentation and isolation
T Kato, H Hinoo, J Shoji, K Matsumoto, T Tanimoto, T Hattori, K Hirooka, E Kondo J Antibiot (Tokyo). 1987 Feb;40(2):135-8. doi: 10.7164/antibiotics.40.135.
New monobactams, PB-5266 A, B and C were isolated from the culture filtrate of Cytophaga johnsonae PB-5266 by various types of column chromatography and preparative reverse phase HPLC. PB-5266 A, B and C exhibited weak antibacterial activity against a sensitive mutant of Escherichia coli to beta-lactam antibiotics.

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