PB-5266 A
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| Category | Antibiotics |
| Catalog number | BBF-03330 |
| CAS | 108065-94-7 |
| Molecular Weight | 437.39 |
| Molecular Formula | C13H19N5O10S |
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Description
PB-5266 A is a monobactam antibiotic isolated from the culture filtrate of Cytophaga johnsonae PB-5266. It exhibited weak antibacterial activity against a sensitive mutant of Escherichia coli to beta-lactam antibiotics.
Specification
| Synonyms | Antibiotic PB-5266A |
| IUPAC Name | (3R)-3-[[(E)-4-amino-2-[[(2R)-2-[[(2S)-2,3-dihydroxypropanoyl]amino]propanoyl]amino]-4-oxobut-2-enoyl]amino]-2-oxoazetidine-1-sulfonic acid |
| Canonical SMILES | CC(C(=O)NC(=CC(=O)N)C(=O)NC1CN(C1=O)S(=O)(=O)O)NC(=O)C(CO)O |
| InChI | InChI=1S/C13H19N5O10S/c1-5(15-12(24)8(20)4-19)10(22)16-6(2-9(14)21)11(23)17-7-3-18(13(7)25)29(26,27)28/h2,5,7-8,19-20H,3-4H2,1H3,(H2,14,21)(H,15,24)(H,16,22)(H,17,23)(H,26,27,28)/b6-2+/t5-,7-,8+/m1/s1 |
| InChI Key | TXLOYBYUSQMOIL-RZSWNVQPSA-N |
Reference Reading
1. PB-5266 A, B and C, new monobactams. II. Physico-chemical properties and chemical structures
T Kato, H Hinoo, Y Terui, J Nishikawa, Y Nakagawa, Y Ikenishi, J Shoji J Antibiot (Tokyo). 1987 Feb;40(2):139-44. doi: 10.7164/antibiotics.40.139.
The chemical structures of three new monobactams, PB-5266 A, B and C, were elucidated by their physico-chemical properties and spectrometric studies. In contrast to previously described monobactams, they all possess a dehydroasparagine residue.
2. PB-5266 A, B and C, new monobactams. I. Taxonomy, fermentation and isolation
T Kato, H Hinoo, J Shoji, K Matsumoto, T Tanimoto, T Hattori, K Hirooka, E Kondo J Antibiot (Tokyo). 1987 Feb;40(2):135-8. doi: 10.7164/antibiotics.40.135.
New monobactams, PB-5266 A, B and C were isolated from the culture filtrate of Cytophaga johnsonae PB-5266 by various types of column chromatography and preparative reverse phase HPLC. PB-5266 A, B and C exhibited weak antibacterial activity against a sensitive mutant of Escherichia coli to beta-lactam antibiotics.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
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