PB-5266 B
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| Category | Antibiotics |
| Catalog number | BBF-03331 |
| CAS | 108065-95-8 |
| Molecular Weight | 453.38 |
| Molecular Formula | C13H19N5O11S |
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Description
PB-5266 B is a monobactam antibiotic isolated from the culture filtrate of Cytophaga johnsonae PB-5266. It exhibited weak antibacterial activity against a sensitive mutant of Escherichia coli to beta-lactam antibiotics.
Specification
| Synonyms | Antibiotic PB-5266B |
| IUPAC Name | (3R)-3-[[(E)-4-amino-2-[[(2R)-2-[[(2S)-2,3-dihydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobut-2-enoyl]amino]-2-oxoazetidine-1-sulfonic acid |
| Canonical SMILES | C1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=CC(=O)N)NC(=O)C(CO)NC(=O)C(CO)O |
| InChI | InChI=1S/C13H19N5O11S/c14-9(22)1-5(10(23)16-6-2-18(13(6)26)30(27,28)29)15-11(24)7(3-19)17-12(25)8(21)4-20/h1,6-8,19-21H,2-4H2,(H2,14,22)(H,15,24)(H,16,23)(H,17,25)(H,27,28,29)/b5-1+/t6-,7-,8+/m1/s1 |
| InChI Key | WTKJMGUBCARKJM-RHXHYQRSSA-N |
Reference Reading
1. PB-5266 A, B and C, new monobactams. I. Taxonomy, fermentation and isolation
T Kato, H Hinoo, J Shoji, K Matsumoto, T Tanimoto, T Hattori, K Hirooka, E Kondo J Antibiot (Tokyo). 1987 Feb;40(2):135-8. doi: 10.7164/antibiotics.40.135.
New monobactams, PB-5266 A, B and C were isolated from the culture filtrate of Cytophaga johnsonae PB-5266 by various types of column chromatography and preparative reverse phase HPLC. PB-5266 A, B and C exhibited weak antibacterial activity against a sensitive mutant of Escherichia coli to beta-lactam antibiotics.
2. PB-5266 A, B and C, new monobactams. II. Physico-chemical properties and chemical structures
T Kato, H Hinoo, Y Terui, J Nishikawa, Y Nakagawa, Y Ikenishi, J Shoji J Antibiot (Tokyo). 1987 Feb;40(2):139-44. doi: 10.7164/antibiotics.40.139.
The chemical structures of three new monobactams, PB-5266 A, B and C, were elucidated by their physico-chemical properties and spectrometric studies. In contrast to previously described monobactams, they all possess a dehydroasparagine residue.
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
