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PD-118576

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Category Antibiotics
Catalog number BBF-03333
CAS 100632-37-9
Molecular Weight 576.8
Molecular Formula C33H52O8

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Capabilities & Facilities

Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

PD-118576 is an antitumor macrolide antibiotic produced by Streptomyces sp. WP 3913. It exhibits moderate activity against bacteria and fungi.

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Synonyms PD 118576; PD118576; PD-118,576; PD 118,576; PD118,576;
IUPAC Name (3E,5E,11E,13Z)-16-[(E)-3,9-dihydroxy-4,8-dimethyl-5-oxodec-6-en-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Canonical SMILES CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C(=O)C=CC(C)C(C)O)O)OC)C
InChI InChI=1S/C33H52O8/c1-19-12-11-13-28(39-9)32(25(7)31(37)24(6)27(35)15-14-21(3)26(8)34)41-33(38)29(40-10)18-20(2)17-23(5)30(36)22(4)16-19/h11-15,17-18,21-26,28,30-32,34,36-37H,16H2,1-10H3/b13-11-,15-14+,19-12+,20-17+,29-18+
InChI Key LZUOOFGZMKQIEU-HUPOZIRGSA-N
Antibiotic Activity Spectrum neoplastics (Tumor); fungi
1. Isolation and structure determination of new macrolide antibiotics
G M Hatfield, R W Woodard, J K Son J Nat Prod. 1992 Jun;55(6):753-9. doi: 10.1021/np50084a008.
Three new bafilomycin-like compounds PD 118,576-A1 [1], PD 118,576-A2 [2], and PD 118,576-A3 [3] were isolated from a new soil Streptomyces species (WP 3913). The structures of PD 118,576-A1, PD 118,576-A2, and PD 118,576-A3 were elucidated on the basis of spectroscopic studies including 2D nmr.
2. PD 118,576: a new antitumor macrolide antibiotic
J H Wilton, G C Hokanson, J C French J Antibiot (Tokyo). 1985 Nov;38(11):1449-52. doi: 10.7164/antibiotics.38.1449.
The isolation and properties of PD 118,576, a new cytotoxic antibiotic obtained from the culture broth of a Streptomyces sp., are described. The structure of this compound was established by spectral analyses of the parent compound and its tri-O-acetyl derivative. PD 118,576 proved to be related to the bafilomycins and therefore is a new member of this recently discovered family of macrolide antibiotics.

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