Pentostatin
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Category | Antineoplastic |
Catalog number | BBF-04083 |
CAS | 53910-25-1 |
Molecular Weight | 268.27 |
Molecular Formula | C11H16N4O4 |
Purity | >98% |
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Capabilities & Facilities
Fermentation Lab
4 R&D and scale-up labs
2 Preparative purification labs
Fermentation Plant
Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)
Product Description
Pentostatin is an adenosine deaminase inhibitor isolated from Streptomyces and effective against cancer cell lines. Pentostatin is a purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells. Pentostatin has been reported to display strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia.
- Specification
- Properties
- Toxicity
- Reference Reading
- Spectrum
- Price Product List
Synonyms | 2'-deoxycoformycin; co-vidarabine; deoxycoformycin; covidarabine; deoxycoformycin; Nipent; (R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol |
Storage | Store at -20°C |
IUPAC Name | (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol |
Canonical SMILES | C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O |
InChI | InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8-,9+/m1/s1 |
InChI Key | FPVKHBSQESCIEP-XAVMHZPKSA-N |
Source | Streptomyces sp. |
Appearance | White to Off-white Solid |
Antibiotic Activity Spectrum | neoplastics (Tumor) |
Boiling Point | 646°C at 760 mmHg |
Melting Point | 220-225°C |
Density | 1.81 g/cm3 |
Solubility | Soluble in ethanol, methanol, DMF, DMSO |
LogP | -1.1 |
Carcinogenicity | No indication of carcinogenicity to humans (not listed by IARC). |
Mechanism Of Toxicity | Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase). |
Toxicity | LD50 = 128 mg/kg (mouse). |
Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive

Experimental Conditions
Ionization Energy: 70 eV
Chromatography Type: Gas Chromatography Column (GC)
Instrument Type: Single quadrupole, spectrum predicted by CFM-ID(EI)
Mass Resolution: 0.0001 Da
Molecular Formula: C11H16N4O4
Molecular Weight (Monoisotopic Mass): 268.1172 Da
Molecular Weight (Avergae Mass): 268.2691 Da
Predicted LC-MS/MS Spectrum - 10V, Positive

Experimental Conditions
Collision Energy: 10 eV
Instrument Type: QTOF (generic), spectrum predicted by CFM-ID
Mass Resolution: 0.0001 Da
Molecular Formula: C11H16N4O4
Molecular Weight (Monoisotopic Mass): 268.1172 Da
Molecular Weight (Avergae Mass): 268.2691 Da
1H NMR Spectrum

Experimental Conditions
Nucleus: 1H
Frequency: 100
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Bio Calculators
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
