Phenazostatin A

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Category Others
Catalog number BBF-02386
CAS
Molecular Weight 460.48
Molecular Formula C28H20N4O3

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Description

It is produced by the strain of Str. sp. 833. It is a phenazine Substance that has the protective effect of new neuron cells. It can scavenge free radicals, protect N18-RE 105 nerve cells from glutamate toxicity, and inhibit lipid peroxidation. It inhibits glutamate toxicity in N18-RE-105 cells with EC50 of 0.34 μg/mL.

Specification

IUPAC Name methyl 6-(1-phenazin-2-yloxyethyl)phenazine-1-carboxylate
Canonical SMILES CC(C1=C2C(=CC=C1)N=C3C(=N2)C=CC=C3C(=O)OC)OC4=CC5=NC6=CC=CC=C6N=C5C=C4
InChI InChI=1S/C28H20N4O3/c1-16(35-17-13-14-22-25(15-17)30-21-10-4-3-9-20(21)29-22)18-7-5-11-23-26(18)31-24-12-6-8-19(27(24)32-23)28(33)34-2/h3-16H,1-2H3
InChI Key UMCSSUSEJCLNON-UHFFFAOYSA-N

Properties

Appearance Yellow Crystal
Solubility Soluble in Chloroform, Methanol

Reference Reading

1. New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp
W G Kim, I J Ryoo, B S Yun, K Shin-ya, H Seto, I D Yoo J Antibiot (Tokyo). 1997 Sep;50(9):715-21. doi: 10.7164/antibiotics.50.715.
Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 microM, respectively.

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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