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Phenazostatin B

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Category Others
Catalog number BBF-02387
CAS
Molecular Weight 530.57
Molecular Formula C32H26N4O4

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Fermentation Lab

4 R&D and scale-up labs

2 Preparative purification labs

Fermentation Plant

Semi pilot, pilot and industrial plant 4 Manufacturing sites 7 Production lines at pilot scale 100+ Reactors of 30-4000 L; 170+ reactors of 20 KL-30 KL; 24+ reactors of >100 KL 2 Hydrogenation reactors (200 L, 4Mpa and 1000L, 4Mpa)

Product Description

It is produced by the strain of Str. sp. 833. It is a phenazine Substance that has the protective effect of new neuron cells. It can scavenge free radicals, protect N18-RE 105 nerve cells from glutamate toxicity, and inhibit lipid peroxidation. It inhibits glutamate toxicity in N18-RE-105 cells with EC50 of 0.33 μg/mL.

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  • Properties
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IUPAC Name methyl 6-[3-(6-methoxycarbonylphenazin-1-yl)butan-2-yl]phenazine-1-carboxylate
Canonical SMILES CC(C1=C2C(=CC=C1)N=C3C(=N2)C=CC=C3C(=O)OC)C(C)C4=C5C(=CC=C4)N=C6C(=N5)C=CC=C6C(=O)OC
InChI InChI=1S/C32H26N4O4/c1-17(19-9-5-13-23-27(19)33-25-15-7-11-21(29(25)35-23)31(37)39-3)18(2)20-10-6-14-24-28(20)34-26-16-8-12-22(30(26)36-24)32(38)40-4/h5-18H,1-4H3
InChI Key WAOUDSYSWNZZKK-UHFFFAOYSA-N
Appearance Yellow Crystal
Solubility Soluble in Chloroform, Methanol
1. New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp
W G Kim, I J Ryoo, B S Yun, K Shin-ya, H Seto, I D Yoo J Antibiot (Tokyo). 1997 Sep;50(9):715-21. doi: 10.7164/antibiotics.50.715.
Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 microM, respectively.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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Tip: Chemical formula is case sensitive. C22H30N4O c22h30n40
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